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Doublecortin-Immunoreactive Neuronal Precursors in the Dentate Gyrus of Spontaneously Hypertensive Rats at Various Age Stages: Comparison with Sprague-Dawley Rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, In Koo | - |
dc.contributor.author | Yoon, Yeo Sung | - |
dc.contributor.author | Choi, Jung Hoon | - |
dc.contributor.author | Yoo, Ki-Yeon | - |
dc.contributor.author | Yi, Sun Shin | - |
dc.contributor.author | Chung, Dae Won | - |
dc.contributor.author | Kim, Hyun-Jin | - |
dc.contributor.author | Kim, Chung-Seop | - |
dc.contributor.author | Do, Seon-Gil | - |
dc.contributor.author | Sung, Je Kyeong | - |
dc.contributor.author | Lee, In Se | - |
dc.contributor.author | Won, Moo-Ho | - |
dc.date.accessioned | 2009-08-25T07:40:17Z | - |
dc.date.available | 2009-08-25T07:40:17Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | J. Vet. Med. Sci. 70: 373-377 | en |
dc.identifier.issn | 0916-7250 (online) | - |
dc.identifier.issn | 1347-7439 (print) | - |
dc.identifier.uri | https://hdl.handle.net/10371/7784 | - |
dc.description.abstract | Spontaneously hypertensive rats (SHRs) are widely accepted in medical research because this model has been used for studies in neurodegenerative diseases such as vascular dementia and stroke. In the present study, we observed newly generated neuronal precursors using doublecortin (DCX, a marker of neural proliferation and differentiation) in the subgranular zone of the dentate gyrus in SHRs compared to Sprague-Dawley rats (SDRs) at various age stages. DCX immunoreactivity, immunoreactive cell numbers and its protein level in the dentate gyrus of the SHRs were higher than those in the SDRs at postnatal month 1 (PM 1). At PM 8, DCX immunoreactivity, immunoreactive cell numbers and protein levels in both groups were markedly decreased compared to those at PM 1; however, they were higher than those in the SDRs. They were decreased in the both groups with age: DCX immunoreactive cells in the SDRs were few at PM 12. Our results indicate that newly generated neuronal precursors are more abundant in SHRs than in SDRs during their life. | en |
dc.description.sponsorship | The authors would like to
thank Mr. Seok Han, Mr. Seung Uk Lee and Ms. Hyun Sook Kim for their technical help in this study. This work was supported by the stem cell research program of Ministry of Science & Technology, grants (M10641450002-07N4145– 00210). | en |
dc.language.iso | en | - |
dc.publisher | Japanese Society of Veterinary Science | en |
dc.subject | development | en |
dc.subject | doublecortin | en |
dc.subject | neurogenesis | en |
dc.subject | spontaneously hypertensive rat | en |
dc.title | Doublecortin-Immunoreactive Neuronal Precursors in the Dentate Gyrus of Spontaneously Hypertensive Rats at Various Age Stages: Comparison with Sprague-Dawley Rats | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 황인구 | - |
dc.contributor.AlternativeAuthor | 윤여성 | - |
dc.contributor.AlternativeAuthor | 최정훈 | - |
dc.contributor.AlternativeAuthor | 유기연 | - |
dc.contributor.AlternativeAuthor | 이순신 | - |
dc.contributor.AlternativeAuthor | 정대원 | - |
dc.contributor.AlternativeAuthor | 김현진 | - |
dc.contributor.AlternativeAuthor | 김충섭 | - |
dc.contributor.AlternativeAuthor | 도선길 | - |
dc.contributor.AlternativeAuthor | 성제경 | - |
dc.contributor.AlternativeAuthor | 이인세 | - |
dc.contributor.AlternativeAuthor | 원무호 | - |
dc.identifier.doi | 10.1292/jvms.70.373 | - |
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