S-Space College of Medicine/School of Medicine (의과대학/대학원) Biomedical Engineering (의공학전공) Journal Papers (저널논문_의공학전공)
Development of a Cold Dialysate Regeneration System for Home Hemodialysis
- Kim, Ji Hyun; Kim, Jeong Chul; Moon, Jin-Hee; Park, Joong Yull; Kang, Eungtaek; Min, Byoung Goo; Ronco, Claudio; Kim, Hee Chan; Lee, Kyoung Kap
- Issue Date
- BLOOD PURIFICATION; Vol.28 2; 84-92
- Dialysate; Dialysate regeneration system; Artificial kidney; Activated carbon; Desorption; Adsorption; Home hemodialysis
- Background/Aims: Because longer and/or more frequent dialysis has potential clinical benefits, home hemodialysis (HHD) systems should provide flexible renal replacement therapies. We propose a new cold dialysate regeneration system that requires 10 1 per treatment for HHD. Methods: We designed a dialysate regeneration system using cold dialysate and 2 activated carbon columns alternatively switched between adsorption and desorption. Urea adsorption ratios were compared in three different conditions; cold dialysate (5.7 degrees C), normal dialysate (36.8 degrees C), and cold dialysate with washing. In vivo tests (n = 8) were conducted to validate this system. Results: The urea removal ratios were 20.0 +/- 1.7% in cold dialysate, 36.0 +/- 1.7% in normal dialysate, and 82.5 +/- 1.2% in cold dialysate with washing. In animal experiments, the urea reduction ratio was 60.9 +/- 6.3%, Kt/V was 1.0 +/- 0.2, and serum electrolytes remained stable. Conclusion: The proposed cold dialysate regeneration system using a small volume of dialysate will be useful for HHD. Copyright (C) 2009 S. Karger AG, Basel
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