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Fibrin Glue Reduces the Duration of Lymphatic Drainage after Lumpectomy and Level II or III Axillary Lymph Node Dissection for Breast Cancer: A Prospective Randomized Trial

Cited 21 time in Web of Science Cited 22 time in Scopus
Authors
Ko, Eunyoung; Han, Wonshik; Cho, Jihyoung; Lee, Jong Won; Jung, So-Youn; Hwang, Ki-Tae; Noh, Dong-Young; Kim, Eun-Kyu; Kang, So Young
Issue Date
2009-02
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE; Vol.24(1); 92-96
Keywords
Fibrin Tissue AdhesiveAxillary Lymph Node ExcisionBreast NeoplasmsLymphatic Drainage
Abstract
This randomized prospective study investigated the effect of fibrin glue use on drainage duration and overall drain output after lumpectomy and axillary dissection in breast cancer patients. A total of 100 patients undergoing breast lumpectomy and axillary dissection were randomized to a fibrin glue group (N=50; glue sprayed onto the axillary dissection site) or a control group (N=50). Outcome measures were drainage duration, overall drain output, and incidence of seroma. Overall, the fibrin glue and control groups were similar in terms of drainage duration, overall drain output, and incidence of seroma. However, subgroup analysis showed that fibrin glue use resulted in a shorter drainage duration (3.5 vs. 4.7 days; p=0.0006) and overall drain output (196 vs. 278 mL; p=0.0255) in patents undergoing level II or III axillary dissection. Fibrin glue use reduced drainage duration and overall drain output in breast cancer patients undergoing a lumpectomy and level II or III axillary dissection.
ISSN
1011-8934
Language
English
URI
http://hdl.handle.net/10371/77853
DOI
https://doi.org/10.3346/jkms.2009.24.1.92
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College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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