Browse

Reusable Ultrasonic Tissue Mimicking Hydrogels Containing Nonionic Surface-Active Agents for Visualizing Thermal Lesions

Cited 23 time in Web of Science Cited 23 time in Scopus
Issue Date
2010-01
Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
Citation
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING; Vol.57 1; 194-202
Keywords
High-intensity focused ultrasound (HIFU)nonionic surface-active agent (NiSAA)thermal lesionvisualizationtissue mimicking phantompolyacrylamide hydrogel
Abstract
The present study aims to identify a new recipe for reusable tissue mimicking phantoms that allows the optical visualization of thermal lesions produced in various applications of therapeutic ultrasound where thermal mechanisms are important. The phantom was made of polyacrylamide hydrogel containing a nonionic surface-active agent (NiSAA) as a temperature-sensitive indicator. Threshold temperature above which a thermal lesion is regarded to be formed in the phantom is controlled by selecting an NiSAA. In the present study, three NiSAAs of polyoxyethylene alkyl ether series with nominal clouding points of 66 degrees C, 70 degrees C, and 80 degrees C were chosen. Test phantoms were prepared with polyacrylamide hydrogel, corn syrup and NiSAAs [5% (w/v)]. Key acoustic properties of the three NiSAA hydrogels were found to be similar to those of human liver. The phantoms were optically transparent at room temperature (25 degrees C) and became opaque after exceeding the clouding points. The transparency was recovered on cooling, although the system demonstrated hysteresis. The phantoms were tested both in their ability to provide visualization of thermal lesions produced by high-intensity focused ultrasound and also to examine any characteristic differences in the shape of the lesions formed at different threshold temperatures. The present study suggests that the NiSAA polyacrylamide hydrogel will be of a practical use in quality assurance in various applications of therapeutic ultrasound where thermal mechanisms are important.
ISSN
0018-9294
Language
English
URI
https://hdl.handle.net/10371/77884
DOI
https://doi.org/10.1109/TBME.2009.2031314
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Biomedical Engineering (의공학전공)Journal Papers (저널논문_의공학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse