Publications

Detailed Information

Aqueous Humor Concentration of Bevacizumab After Subconjunctival Injection in Rabbit

Cited 14 time in Web of Science Cited 16 time in Scopus
Authors

Kim, Moon Jung; Han, Eui Seok; Kim, JaeWoo; Kim, Tae-Woo

Issue Date
2010-02
Publisher
MARY ANN LIEBERT INC
Citation
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS; Vol.26 1; 49-54
Abstract
Purpose: To investigate whether bevacizumab may be delivered into the anterior chamber after subconjunctival administration and its pharmacokinetics in aqueous humor. Methods: The right eye of 33 rabbits received subconjunctival injection of 2.5 mg of subconjunctival bevacizumab. Three rabbits were sacrificed at each of the following time points: 0.5, 1, 2, 4, 8, 12, 24, 48, 72, 120, 168 h after the injection. Bevacizumab concentrations were measured in aqueous fluid of injected and uninjected eyes and serum using enzyme-linked immunosorbent assay. Results: Bevacizumab was first detected in the aqueous humor of the injected eye at 12 h after the subconjunctival injection. A peak concentration of 70.59 +/- 26.01 ng/mL was achieved at 36 h. Bevacizumab was also detected in the serum and aqueous humor of the uninjected contralateral eye. The concentration in the aqueous humor of the injected eye was lower than in the serum and higher than in the aqueous humor of the uninjected contralateral eye at all time points. Elimination of bevacizumab from the serum and aqueous humor of injected and uninjected eye paralleled with half-life of 57.78 +/- 13.75 h, 27.64 +/- 1.95 h and 28.05 +/- 2.55 h, respectively. Conclusions: We demonstrated that bevacizumab can be delivered into anterior chamber by single subconjunctival injection. Further study is needed to assess whether subconjunctival bevacizumab is clinically useful in patients with neovascular glaucoma.
ISSN
1080-7683
Language
English
URI
https://hdl.handle.net/10371/77903
DOI
https://doi.org/10.1089/jop.2009.0022
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share