Association between Helicobacter pylori infection and Posner-Schlossman syndrome

Abstract

Objective: To investigate possible association between Helicobacter pylori infection and Posner-Schlossman syndrome. Methods: In a prospective study, 40 subjects with Posner-Schlossman syndrome were examined. As a control group, 73 subjects without Posner-Schlossman syndrome were selected for comparison with the study group. All participants underwent serologic analysis for the presence of H. pylori infection by an enzyme-linked immunosorbent assay. Positive rate of serum anti-H. pylori IgG was compared between Posner-Schlossman syndrome patients and control participants. Results: The rate of positive titre (> 15 U/ml) of H. pylori was 80.0% in the Posner-Schlossman syndrome group and 56.2% in control group, showing significant difference (Fischer`s exact, P = 0.014). Multivariate analysis adjusted for various systemic factors revealed that positive titre of anti-H. pylori IgG was a significant risk factor for Posner-Schlossman syndrome with an odds ratio, (4.84, 95.0% CI: 1.10-21.24, P = 0.037). Conclusions: H. pylori infection occurred significantly more often in Posner-Schlossman syndrome patients. This study suggests that exposure to H. pylori infection is associated with Posner-Schlossman syndrome in Korea. Eye (2010) 24, 64-69; doi: 10.1038/eye.2009.34; published online 20 February 2009