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Protein Expression Profiling of Primary Mammary Epithelial Cells Derived from MMTV-neu Mice Revealed that HER2/NEU-Driven Changes in Protein Expression Are Functionally Clustered
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dc.contributor.author | Park, Sungwoo | - |
dc.contributor.author | Lee, Kyung-min | - |
dc.contributor.author | Ju, Ji-hyun | - |
dc.contributor.author | Kim, Jaeyoon | - |
dc.contributor.author | Lee, Taehoon | - |
dc.contributor.author | Shin, Incheol | - |
dc.contributor.author | Noh, Dong-Young | - |
dc.date.accessioned | 2012-06-29T05:32:08Z | - |
dc.date.available | 2012-06-29T05:32:08Z | - |
dc.date.issued | 2010-01 | - |
dc.identifier.citation | IUBMB LIFE; Vol.62 1; 41-50 | ko_KR |
dc.identifier.issn | 1521-6543 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77942 | - |
dc.description.abstract | MMTV-neu transgenic mice overexpressing NEU in their mammary glands develop tumor after 6 months of age. To find a novel protein biomarker using this mouse model, we identified and characterized the proteins that were differently expressed between primary mammary epithelial cells from 2 months old MMTV-neu heterozygote mice and wild type (WT) littermates using two-dimensional digest (ChemDigest (TM)/Trypsin)-LC-MS/MS. The differentially expressed proteins were selected and analyzed using DAVID Bioinformatics resource. The proteins involved in anti-apoptosis, purine metabolism, ribosome and proteasome functions were upregulated, whereas cell adhesion-related proteins were downregulated in PMECs from MMTV-neu mice when compared with WT PMECs. The results indicate that several functional units are coregulated by HER2/NEU. We hypothesize that these changes in the cellular proteome may be responsible for early onset of HER2/NEU-driven tumorigenesis. (C) 2009 IUBMB IUBMB Life, 62(1): 41-50, 2010 | ko_KR |
dc.description.sponsorship | This work is supported by FPR08A2-080 of 21st Century Frontier
Functional Proteomics Project from Korean Ministry of Science and Technology and by a grant of the Korea Healthcare technology R&D Project, Ministry of Welfare and Family Affairs, Republic of Korea, (A084466). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | JOHN WILEY & SONS INC | ko_KR |
dc.subject | proteonomics | ko_KR |
dc.subject | signal transduction | ko_KR |
dc.subject | HER2/NEU | ko_KR |
dc.title | Protein Expression Profiling of Primary Mammary Epithelial Cells Derived from MMTV-neu Mice Revealed that HER2/NEU-Driven Changes in Protein Expression Are Functionally Clustered | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 박성우 | - |
dc.contributor.AlternativeAuthor | 이경민 | - |
dc.contributor.AlternativeAuthor | 주지현 | - |
dc.contributor.AlternativeAuthor | 김재윤 | - |
dc.contributor.AlternativeAuthor | 노동영 | - |
dc.contributor.AlternativeAuthor | 이태훈 | - |
dc.contributor.AlternativeAuthor | 신인철 | - |
dc.identifier.doi | 10.1002/iub.276 | - |
dc.citation.journaltitle | IUBMB LIFE | - |
dc.description.citedreference | Lee HJ, 2007, NAT CELL BIOL, V9, P1303, DOI 10.1038/ncb1650 | - |
dc.description.citedreference | Ursini-Siegel J, 2007, NAT REV CANCER, V7, P389, DOI 10.1038/nrc2127 | - |
dc.description.citedreference | Heidel JD, 2007, CLIN CANCER RES, V13, P2207, DOI 10.1158/1078-0432.CCR-06-2218 | - |
dc.description.citedreference | Duxbury MS, 2007, BIOCHEM BIOPH RES CO, V354, P190, DOI 10.1016/j.bbrc.2006.12.177 | - |
dc.description.citedreference | Elias JE, 2007, NAT METHODS, V4, P207, DOI 10.1038/nmeth1019 | - |
dc.description.citedreference | Perkins ND, 2007, NAT REV MOL CELL BIO, V8, P49, DOI 10.1038/nrm2083 | - |
dc.description.citedreference | NAKAMURA T, 2007, BIOTECHNOL GENET ENG, V24, P147 | - |
dc.description.citedreference | Spiegel EK, 2006, MOL GENET METAB, V89, P19, DOI 10.1016/j.ymgme.2006.04.018 | - |
dc.description.citedreference | Kobayashi T, 2006, INT J MOL MED, V18, P161 | - |
dc.description.citedreference | Wang H, 2006, BMC CANCER, V6, DOI 10.1186/1471-2407-6-91 | - |
dc.description.citedreference | Bee A, 2006, CLIN CANCER RES, V12, P2061, DOI 10.1158/1078-0432.CCR-05-2445 | - |
dc.description.citedreference | Zhang DH, 2005, MOL CELL PROTEOMICS, V4, P1686, DOI 10.1074/mcp.M400221-MCP200 | - |
dc.description.citedreference | Romond EH, 2005, NEW ENGL J MED, V353, P1673 | - |
dc.description.citedreference | Abd El-Rehim DM, 2005, INT J CANCER, V116, P340, DOI 10.1002/ijc.21004 | - |
dc.description.citedreference | Landis MD, 2005, ONCOGENE, V24, P5173, DOI 10.1038/sj.onc.1208712 | - |
dc.description.citedreference | Mani A, 2005, J CLIN ONCOL, V23, P4776, DOI 10.1200/JCO.2005.05.081 | - |
dc.description.citedreference | Wang YX, 2005, NAT GENET, V37, P750, DOI 10.1038/ng1587 | - |
dc.description.citedreference | Nishino T, 2005, J BIOL CHEM, V280, P24888, DOI 10.1074/jbc.M501830200 | - |
dc.description.citedreference | Linder N, 2005, CLIN CANCER RES, V11, P4372 | - |
dc.description.citedreference | Kasai H, 2005, RESP RES, V6, DOI 10.1186/1465-9921-6-56 | - |
dc.description.citedreference | Barnes CJ, 2005, CLIN CANCER RES, V11, P2868 | - |
dc.description.citedreference | Pende D, 2005, MOL IMMUNOL, V42, P463, DOI 10.1016/j.molimm.2004.07.028 | - |
dc.description.citedreference | Piccart-Gebhart MJ, 2005, EUR J CANCER, V41, P341, DOI 10.1016/j.ejca.2004.09.019 | - |
dc.description.citedreference | Hayden MS, 2004, GENE DEV, V18, P2195, DOI 10.1101/gad.1228704 | - |
dc.description.citedreference | Espana L, 2004, BREAST CANCER RES TR, V87, P33 | - |
dc.description.citedreference | Chen BS, 2004, MOL CELL BIOL, V24, P3983, DOI 10.1128/MCB.24.9.3983-3991.2004 | - |
dc.description.citedreference | Reed JC, 2003, CANCER CELL, V3, P17 | - |
dc.description.citedreference | Woychik NA, 2002, CELL, V108, P453 | - |
dc.description.citedreference | Gharbi S, 2002, MOL CELL PROTEOMICS, V1, P91 | - |
dc.description.citedreference | TSIMBERIDOU AM, 2002, EXPERT REV ANTICANC, V2, P437 | - |
dc.description.citedreference | Frisch SM, 2001, CURR OPIN CELL BIOL, V13, P555 | - |
dc.description.citedreference | Zhu YF, 2001, BREAST CANCER RES TR, V69, P29 | - |
dc.description.citedreference | Ikeda T, 2001, J HUM GENET, V46, P538 | - |
dc.description.citedreference | YARDEN Y, 2001, NAT REV MOL CELL BIO, V2, P137 | - |
dc.description.citedreference | Olayioye MA, 2000, EMBO J, V19, P3159 | - |
dc.description.citedreference | Hatse S, 1999, BIOCHEM PHARMACOL, V58, P539 | - |
dc.description.citedreference | Kohler C, 1999, FEBS LETT, V447, P10 | - |
dc.description.citedreference | Ul Haque MF, 1998, NAT GENET, V20, P157 | - |
dc.description.citedreference | Kurima K, 1998, P NATL ACAD SCI USA, V95, P8681 | - |
dc.description.citedreference | Ross JS, 1998, STEM CELLS, V16, P413 | - |
dc.description.citedreference | Nobumoto M, 1998, J BIOCHEM-TOKYO, V123, P128 | - |
dc.description.citedreference | Edvardsen K, 1997, APMIS, V105, P919 | - |
dc.description.citedreference | DelBufalo D, 1997, FASEB J, V11, P947 | - |
dc.description.citedreference | Wold MS, 1997, ANNU REV BIOCHEM, V66, P61 | - |
dc.description.citedreference | Kumar R, 1996, CLIN CANCER RES, V2, P1215 | - |
dc.description.citedreference | HENRY JL, 1993, CANCER RES, V53, P1403 | - |
dc.description.citedreference | PUJOL JL, 1993, CANCER RES, V53, P61 | - |
dc.description.citedreference | GUY CT, 1992, P NATL ACAD SCI USA, V89, P10578 | - |
dc.description.citedreference | FRIXEN UH, 1991, J CELL BIOL, V113, P173 | - |
dc.description.citedreference | LEMOINE NR, 1990, ONCOGENE, V5, P237 | - |
dc.description.citedreference | BOUCHARD L, 1989, CELL, V57, P931 | - |
dc.description.citedreference | MULLER WJ, 1988, CELL, V54, P105 | - |
dc.description.citedreference | SLAMON DJ, 1987, SCIENCE, V235, P177 | - |
dc.description.citedreference | YAMAMOTO T, 1986, NATURE, V319, P230 | - |
dc.description.citedreference | SCHECHTER AL, 1984, NATURE, V312, P513 | - |
dc.description.tc | 0 | - |
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