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Bc13-dependent stabilization of CtBP1 is crucial for the inhibition of apoptosis and tumor progression in breast cancer
DC Field | Value | Language |
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dc.contributor.author | Choi, Hee June | - |
dc.contributor.author | Lee, Ji Min | - |
dc.contributor.author | Kim, Hyunkyung | - |
dc.contributor.author | Nam, Hye Jin | - |
dc.contributor.author | Kim, Dongha | - |
dc.contributor.author | Noh, Dong-Young | - |
dc.contributor.author | Kim, Jung Hwa | - |
dc.contributor.author | Baek, Sung Hee | - |
dc.contributor.author | Kim, Keun Il | - |
dc.contributor.author | Ko, Enyoung | - |
dc.contributor.author | Shin, Hi-Jai R. | - |
dc.date.accessioned | 2012-06-29T06:18:49Z | - |
dc.date.available | 2012-06-29T06:18:49Z | - |
dc.date.issued | 2010-09-24 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS; Vol.400(3); 396-402 | ko_KR |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://hdl.handle.net/10371/77957 | - |
dc.description.abstract | B-cell lymphoma 3 (Bcl3) is a proto-oncogene upregulated in a wide range of cancers, including breast cancer Although Bcl3 is known to promote cell proliferation and inhibit apoptosis, the molecular mechanisms underlying the proto-oncogenic function of Bcl3 have not been completely elucidated To gain insight into the oncogenic role of Bcl3, we applied a proteomic approach, which led to the identification of C-terminal binding protein 1 (CtBP1) as a binding partner of Bcl3 A PXDLS/R motif embedded in Bcl3 was found to mediate the interaction between Bcl3 and CtBP1, which caused the stabilization of CtBP1 by blocking proteasome-dependent degradation. Apoptotic stimuli-induced degradation of CtBP1 was significantly abolished by the upregulation of Bcl3, leading to the sustained repression of pro-apoptotic gene expression and subsequent inhibition of apoptosis. Intriguingly, a strong positive correlation between the protein levels of Bcl3 and CtBP1 was detected in breast cancer patient samples Our study reveals a novel combinatorial role for Bcl3 and CtBP1, providing an explanation for the acquisition of resistance to apoptosis in cancer cells, which is a major requirement for cancer development. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | ko_KR |
dc.subject | Bcl3 | ko_KR |
dc.subject | CtBP1 | ko_KR |
dc.subject | Ubiquitination | ko_KR |
dc.subject | Cancer | ko_KR |
dc.subject | Apoptosis | ko_KR |
dc.title | Bc13-dependent stabilization of CtBP1 is crucial for the inhibition of apoptosis and tumor progression in breast cancer | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 최희준 | - |
dc.contributor.AlternativeAuthor | 이지민 | - |
dc.contributor.AlternativeAuthor | 김현경 | - |
dc.contributor.AlternativeAuthor | 남혜진 | - |
dc.contributor.AlternativeAuthor | 신희재 | - |
dc.contributor.AlternativeAuthor | 김동하 | - |
dc.contributor.AlternativeAuthor | 고은영 | - |
dc.contributor.AlternativeAuthor | 노동영 | - |
dc.contributor.AlternativeAuthor | 김근일 | - |
dc.contributor.AlternativeAuthor | 김정화 | - |
dc.contributor.AlternativeAuthor | 백성희 | - |
dc.identifier.doi | 10.1016/j.bbrc.2010.08.084 | - |
dc.citation.journaltitle | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
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dc.description.tc | 2 | - |
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