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TUMOR VOLUME REDUCTION RATE MEASURED BY MAGNETIC RESONANCE VOLUMETRY CORRELATED WITH PATHOLOGIC TUMOR RESPONSE OF PREOPERATIVE CHEMORADIOTHERAPY FOR RECTAL CANCER

Cited 67 time in Web of Science Cited 74 time in Scopus
Authors
Yeo, Seung-Gu; Kim, Dae Yong; Kim, Tae Hyun; Jung, Kyung Hae; Chang, Hee Jin; Lim, Seok-Byung; Jeong, Seung-Yong; Choi, Hyo Seong; Park, Ji Won; Hong, Yong Sang
Issue Date
2010-09-01
Publisher
ELSEVIER SCIENCE INC
Citation
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS; Vol.78, no.1; 164-171
Keywords
Tumor volume reduction ratepreoperative chemoradiotherapyrectal cancermagnetic resonance volumetry
Abstract
Purpose: To determine whether the tumor volume reduction rate (TVRR) measured using three-dimensional region-of-interest magnetic resonance volumetry correlates with the pathologic tumor response after preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer. Methods and Materials: The study included 405 patients with locally advanced rectal cancer (cT3-T4) who had undergone preoperative CRT and radical proctectomy. The tumor volume was measured using three-dimensional region-of-interest magnetic resonance volumetry before and after CRT but before surgery. We analyzed the correlation between the TVRR and the pathologic tumor response in terms of downstaging and tumor regression grade (TRG). Downstaging was defined as ypStage 0-I (ypT0-T2N0M0), and the TRG proposed by Dworak et al. was used. Results: The mean TVRR was 65.0% +/- 22.3%. Downstaging and complete regression occurred in 167 (41.2%) and 58 (14.3%) patients, respectively. The TVRRs according to ypT classification (ypT0-T2 vs. ypT3-T4), ypN classification (ypN0 vs. ypN1-N2), downstaging (ypStage 0-I vs. ypStage good regression (TRG 3-4 vs. TRG 1-2), and complete regression (TRG 4 vs. TRG 1-3) were all significantly different (p<.05). When the TVRR was categorized into three groups (<60%, 60-80%, and >80%), the rates of ypT0-T2, ypN0, downstaging, and good regression were all significantly greater for patients with a TVRR of >= 60%, as was the complete regression rate for patients with a TVRR >80% (p<.05). Conclusion: The TVRR measured using three-dimensional region-of-interest magnetic resonance volumetry correlated significantly with the pathologic tumor response in terms of downstaging and TRG after preoperative CRT for locally advanced rectal cancer.
ISSN
0360-3016
Language
English
URI
https://hdl.handle.net/10371/77958
DOI
https://doi.org/10.1016/j.ijrobp.2009.07.1682
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College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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