Publications
Detailed Information
Shank 2 expression coincides with neuronal differentiation in the developing retina
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jeong Hun | - |
dc.contributor.author | Kim, Jin Hyoung | - |
dc.contributor.author | Yang, Esther | - |
dc.contributor.author | Park, Jae-Hwan | - |
dc.contributor.author | Kim, Kyu-Won | - |
dc.contributor.author | Yu, Young Suk | - |
dc.date.accessioned | 2012-07-02T00:11:28Z | - |
dc.date.available | 2012-07-02T00:11:28Z | - |
dc.date.issued | 2009-04-30 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE; Vol.41 4; 236-242 | ko_KR |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78013 | - |
dc.description.abstract | The retinal activity for vision requires a precise synaptic connectivity. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. However, the correlation of Shank 2 expression with neuronal differentiation in the developing retina remains to be elucidated regardless of previous evidences of Shank 2 expression in retina. Herein, we demonstrated that with progression of development, Shank 2 is initially detected in the inner plexiform layer at P2, and then intensively detected in inner plexiform layer, outer plexiform layer, and ganglion cell layer at P14, which was closely colocalized to the neurofilament expression. Shank 2 was, however, not colocalized with glial fibrillary acidic protein. Shank 2 expression was increased in the differentiated retinoblastoma cells, which was mediated by ERK 1/2 activation. Moreover, Shank 2 expression was colocalized with neurofilament at the dendritic region of cells. In conclusion, our data suggests that Shank 2 is expressed in the neurons of the developing retina and could play a critical role in the neuronal differentiation of the developing retina. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY | ko_KR |
dc.subject | cell differentiation | ko_KR |
dc.subject | SHANK 2 protein, human | ko_KR |
dc.subject | retina | ko_KR |
dc.subject | extracellular signal-regulated MAP kinases | ko_KR |
dc.subject | neurons | ko_KR |
dc.title | Shank 2 expression coincides with neuronal differentiation in the developing retina | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김정훈 | - |
dc.contributor.AlternativeAuthor | 김진형 | - |
dc.contributor.AlternativeAuthor | 양에스더 | - |
dc.contributor.AlternativeAuthor | 박재환 | - |
dc.contributor.AlternativeAuthor | 유영석 | - |
dc.contributor.AlternativeAuthor | 김규원 | - |
dc.identifier.doi | 10.3858/emm.2009.41.4.026 | - |
dc.citation.journaltitle | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.description.citedreference | Kim JH, 2007, ONCOL REP, V18, P1373 | - |
dc.description.citedreference | Kim JH, 2007, INT J ONCOL, V31, P585 | - |
dc.description.citedreference | Jung HS, 2006, FEBS LETT, V580, P4969, DOI 10.1016/j.febslet.2006.07.077 | - |
dc.description.citedreference | Haydon PG, 2006, PHYSIOL REV, V86, P1009, DOI 10.1152/physrev.00049.2005 | - |
dc.description.citedreference | Gerrow K, 2006, NEURON, V49, P547, DOI 10.1016/j.neuron.2006.01.015 | - |
dc.description.citedreference | Petralia RS, 2005, MOL CELL NEUROSCI, V29, P436, DOI 10.1016/j.mcn.2005.03.013 | - |
dc.description.citedreference | Roussignol G, 2005, J NEUROSCI, V25, P3560, DOI 10.1523/JNEUROSCI.4354-04.2005 | - |
dc.description.citedreference | Brandstatter JH, 2004, J COMP NEUROL, V475, P551, DOI 10.1002/cne.20194 | - |
dc.description.citedreference | Yang XL, 2004, PROG NEUROBIOL, V73, P127, DOI 10.1016/j.pneurobio.2004.04.002 | - |
dc.description.citedreference | Turrigiano GG, 2004, NAT REV NEUROSCI, V5, P97, DOI 10.1038/nrn1327 | - |
dc.description.citedreference | Vecino E, 2004, INT J DEV BIOL, V48, P965, DOI 10.1387/ijdb.04189lev | - |
dc.description.citedreference | MacLean JN, 2003, NEURON, V37, P109 | - |
dc.description.citedreference | Sala C, 2001, NEURON, V31, P115 | - |
dc.description.citedreference | Sheng M, 2001, P NATL ACAD SCI USA, V98, P7058 | - |
dc.description.citedreference | Sheng M, 2000, J CELL SCI, V113, P1851 | - |
dc.description.citedreference | Lim S, 1999, J BIOL CHEM, V274, P29510 | - |
dc.description.citedreference | Naisbitt S, 1999, NEURON, V23, P569 | - |
dc.description.citedreference | Wong WT, 1998, J NEUROSCI, V18, P8839 | - |
dc.description.citedreference | Brandstatter JH, 1998, VISION RES, V38, P1385 | - |
dc.description.citedreference | Ozawa S, 1998, PROG NEUROBIOL, V54, P581 | - |
dc.description.citedreference | Frade JN, 1996, DEVELOPMENT, V122, P2497 | - |
dc.description.citedreference | Bovolenta P, 1996, J NEUROSCI, V16, P4402 | - |
dc.description.citedreference | COOK JE, 1995, MICROSC RES TECHNIQ, V31, P408 | - |
dc.description.citedreference | MASLIM J, 1986, BRAIN RES, V373, P35 | - |
dc.description.tc | 2 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.