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Age-Related Changes of Calbindin D-28k-Immunoreactive Neurons in the Myenteric Plexus of Gerbil Duodenum
Cited 5 time in
Web of Science
Cited 6 time in Scopus
- Authors
- Issue Date
- 2008
- Publisher
- Japanese Society of Veterinary Science
- Citation
- J. Vet. Med. Sci. 70: 343-348
- Keywords
- aging ; calbindin ; duodenum ; gerbil ; myenteric plexus
- Abstract
- We examined the age-related changes of calbindin D-28k (CB)-immunoreactive neurons and overall populations of neurons in the myenteric plexus of gerbil duodenum using whole mount preparations and immunohistochemistry. The circumference of duodenum increased age-dependently. CB-immunoreactive neurons were observed in all groups, and most of them had the Dogiel type II morphology. The fully developed cobweb-like structures were observed in the myenteric plexus of duodenum at postnatal month (PM) 3 to 24. Although the highest numbers of CB-immunoreactive neurons and overall population were observed in PM 1.5, it is related with significant increase of the size of circumference between PM 1.5 to PM 3. CB-immunoreactive neurons were slightly decreased with age between PM 3 to PM 24. We have also found that whole numbers of myenteric neurons were also significantly decreased in PM 24 group. These results suggest that loss of overall numbers of myenteric neurons and CB-immunoreactive neurons may be related with age-related neurodegeneration and functional loss of duodenum in the gerbil.
- ISSN
- 0916-7250 (print)
1347-7439 (online)
- Language
- English
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