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Fabrication and In Vivo Evaluation of the Electrospun Small Diameter Vascular Grafts Composed of Elastin/PLGA/PCL and Heparin-VEGF

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Issue Date
2010-06
Publisher
KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC
Citation
TISSUE ENGINEERING AND REGENERATIVE MEDICINE; Vol.7 2; 149-154
Keywords
small diameter vascular graftelectrospinning techniquebiomimic scaffoldscell recruit
Abstract
Vascular scaffolds made of synthetic materials have been successfully used for many years for the revascularization of blood vessels with inner diameters >= 6 mm. However, small diameter vascular substitutes (<5 mm) have shown poor patency rates because of the occurrence of thrombosis. In this study, we investigated small diameter(similar to 3 mm) vascular grafts composed of elastin, poly (lactic-co-glycolic acid : PLGA) and polycaprolactone (PCL) fabricated by electrospinning techniques. In addition, heparin and vascular endothelial growth factor (VEGF) were added to the scaffolds to prevent thrombosis on the target incision and promote endothelial cell growth on the surface of scaffolds. The arterial grafts of electrospun elastin/PLGA/PCL vascular prostheses in Sprague-Dawley rats were found to improve the recovery of the incised blood vessel function by promoting migration, attachment and proliferation of endothelial cells onto the vascular scaffolds, thus exploring the potential of electrospun polymer scaffold in vascular graft engineering.
ISSN
1738-2696
Language
Korean
URI
https://hdl.handle.net/10371/78029
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College of Medicine/School of Medicine (의과대학/대학원)Thoracic Surgery (흉부외과학전공)Journal Papers (저널논문_흉부외과학전공)
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