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Diagnostic Benefit of Thyroglobulin Measurement in Fine-Needle Aspiration for Diagnosing Metastatic Cervical Lymph Nodes from Papillary Thyroid Cancer: Correlations with US Features

Cited 45 time in Web of Science Cited 56 time in Scopus
Authors
Jeon, Se Jeong; Kim, Eunhee; Park, Jeong Seon; Son, Kyu Ri; Kim, Yoon Suk; Cho, Bo Youn; Na, Dong Gyu; Park, Do Joon; Baek, Jung Hwan
Issue Date
2009-04
Publisher
KOREAN RADIOLOGICAL SOC
Citation
KOREAN JOURNAL OF RADIOLOGY; Vol.10(2); 106-111
Keywords
Papillary thyroid cancerLymph node metastasisThyroglobulinFine needle aspirationUltrasound (US)
Abstract
Objective: Our goals were to determine the added value of fine-needle aspiration biopsy (FNAB)-thyroglobulin (Tg) measurements over FNAB-cytology alone for diagnosing metastatic nodes, and to determine whether the ultrasound features of lymph nodes can be used to identify lymph nodes that may benefit from FNAB-Tg measurement in patients with papillary thyroid cancer. Materials and Methods: We retrospectively evaluated 76 surgically proven cervical lymph nodes. Twenty-nine patients were awaiting surgery and 18 patients had undergone thyroid surgery for papillary thyroid cancer. Ultrasound-guided FNAB and Tg measurements were performed and the ultrasound features were evaluated. Results: The accuracies, sensitivities, and specificities of FNAB-cytology, FNAB-Tg, and combined FNAB-Tg/cytology were 90%, 80%, and 100%; 92%, 95%, and 90%; and 93%, 96%, and 90%, respectively. The diagnostic sensitivity of FNAB-Tg for metastatic nodes was significantly higher than that of FNAB-cytology (p = 0.011). Furthermore, combined FNAB-Tg/cytology significantly increased sensitivity (p = 0.002) and accuracy (p = 0.03) as compared with FNAB-cytology. Conclusion: Combined FNAB-Tg/cytology is significantly more sensitive and accurate at detecting metastatic nodes than FNAB-cytology alone. FNAB-Tg was better at diagnosing metastases in small lymph nodes.
ISSN
1229-6929
Language
English
URI
http://hdl.handle.net/10371/78030
DOI
https://doi.org/10.3348/kjr.2009.10.2.106
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College of Medicine/School of Medicine (의과대학/대학원)Radiology (영상의학전공)Journal Papers (저널논문_영상의학전공)
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