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Differentiation of Well-Differentiated Hepatocellular Carcinomas From Other Hepatocellular Nodules in Cirrhotic Liver: Value of SPIO-Enhanced MR Imaging at 3.0 Tesla
DC Field | Value | Language |
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dc.contributor.author | Park, Hee Sun | - |
dc.contributor.author | Lee, Jeong-Min | - |
dc.contributor.author | Kim, Se Hyung | - |
dc.contributor.author | Chang, Samuel | - |
dc.contributor.author | Han, Joon Koo | - |
dc.contributor.author | Choi, Byung Ihn | - |
dc.contributor.author | Kim, Soo Jin | - |
dc.date.accessioned | 2012-07-02T05:06:40Z | - |
dc.date.available | 2012-07-02T05:06:40Z | - |
dc.date.issued | 2009-02 | - |
dc.identifier.citation | JOURNAL OF MAGNETIC RESONANCE IMAGING; Vol.29 2; 328-335 | ko_KR |
dc.identifier.issn | 1053-1807 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78077 | - |
dc.description.abstract | Purpose: To determine the diagnostic value of superparamagnetic iron oxide (SPIO)-enhanced MRI for the differentiation of well-differentiated hepatocellular carcinomas (WD-HCCs) from other hepatocellular nodules in cirrhotic liver. Materials and Methods: This study included 114 patients with 216 histologically confirmed hepatocellular nodules, i.e., 23 dysplastic nodules (DNs). 37 WD-HCCs. and 156 moderately or poorly differentiated HCCs (MD-/PD HCCs), who underwent SPIO-enhanced MRI at 3.0T. MRI included T2-weighted fast-spin echo and T2*-weighted gradient recalled echo (GRE) sequences before and after administration of ferucarbotran. The contrast-to-noise ratio (CNR) of the lesion was calculated. Reviewers analyzed signal intensity (SI) of the nodules and their enhancement features on SPIO-enhanced images. Sensitivity, specificity. positive predictive value, negative predictive value. and accuracy in the diagnosis of WD-HCC were also calculated. Results: The mean CNR of WD-HCC was significantly higher than that of DN on T2*-weighted image. Incomplete high SI on SPIO-enhanced T2*-weighted images were seen in 56.8% of WD-HCC. The most prevalent enhancement features of WD-HCCs on SPIO-enhanced T2*-weighted images, were iso SI with high SI foci [32.5% (12/37)] and homogenous subtle high SI [24.3% (9/37)]. Alternatively, 22 of 23 DNs (95.7%) showed low- or iso SI, and 145 of 156 (94.9%) MD-/PD HCCs showed strong high SI. When iso SI with high SI foci or subtle homogenous high SI nodule was considered as diagnostic criteria for WD-HCC, we could identify 56.8% of the WD-HCCs but only 4.4% of the DNs and 3.2% of the MD-/PD HCCs. Conclusion: WD-HCCs have characteristic enhancement features that differentiate them from DNs and MD-/PD HCCs on SPIO-enhanced 3.0T MRI. The lesion conspicuity was better on T2*-weighted images than that on T2-weighted images. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | JOHN WILEY & SONS INC | ko_KR |
dc.subject | hepatocellular carcinoma | ko_KR |
dc.subject | dysplastic nodule | ko_KR |
dc.subject | superparamagnetic iron oxide | ko_KR |
dc.subject | magnetic resonance imaging | ko_KR |
dc.title | Differentiation of Well-Differentiated Hepatocellular Carcinomas From Other Hepatocellular Nodules in Cirrhotic Liver: Value of SPIO-Enhanced MR Imaging at 3.0 Tesla | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 박희선 | - |
dc.contributor.AlternativeAuthor | 이정민 | - |
dc.contributor.AlternativeAuthor | 김세형 | - |
dc.contributor.AlternativeAuthor | 장사무엘 | - |
dc.contributor.AlternativeAuthor | 김수진 | - |
dc.contributor.AlternativeAuthor | 한준구 | - |
dc.contributor.AlternativeAuthor | 최병인 | - |
dc.identifier.doi | 10.1002/jmri.21615 | - |
dc.citation.journaltitle | JOURNAL OF MAGNETIC RESONANCE IMAGING | - |
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dc.description.tc | 9 | - |
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