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In Vivo MR Imaging of Magnetically Labeled Mesenchymal Stem Cells in a Rat Model of Renal Ischemia
DC Field | Value | Language |
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dc.contributor.author | Jung, Sung Il | - |
dc.contributor.author | Kim, Seung Hyup | - |
dc.contributor.author | Kim, Hyo-Cheol | - |
dc.contributor.author | Son, Kyu Ri | - |
dc.contributor.author | Moon, Woo Kyung | - |
dc.contributor.author | Choi, Jong-Sun | - |
dc.contributor.author | Sung, Chang-Kyu | - |
dc.contributor.author | Moon, Min Hoan | - |
dc.contributor.author | Kim, Hoe Suk | - |
dc.contributor.author | Chung, Se Young | - |
dc.date.accessioned | 2012-07-02T05:34:06Z | - |
dc.date.available | 2012-07-02T05:34:06Z | - |
dc.date.issued | 2009-06 | - |
dc.identifier.citation | KOREAN JOURNAL OF RADIOLOGY; Vol.10 3; 277-284 | ko_KR |
dc.identifier.issn | 1229-6929 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78084 | - |
dc.description.abstract | Objective: This study was designed to evaluate in vivo MR imaging for the depiction of intraarterially injected superparamagnetic iron oxide (SPIO)-labeled mesenchymal stem cells (MSCs) in an experimental rat model of renal ischemia. Materials and Methods: Left renal ischemia was induced in 12 male Sprague-Dawley rats by use of the catheter lodging method. In vivo MR signal intensity variations depicted on T2*-weighted sequences were evaluated in both the left and right kidneys prior to injection (n = 2), two hours (n = 4), 15 hours (n = 2), 30 hours (n = 2) and 72 hours (n = 2) after injection of SPIO-labeled MSCs in both kidneys. Signal intensity variations were correlated with the number of Prussian blue stain-positive cells as visualized in histological specimens. Results: In an in vivo study, it was determined that there was a significant difference in signal intensity variation for both the left and right cortex (40.8 +/- 4.12 and 26.4 +/- 7.92, respectively) and for both the left and right medulla (23.2 +/- 3.32 and 15.2 +/- 3.31, respectively) until two hours after injection (p < 0.05). In addition, signal intensity variation in the left renal cortex was well correlated with the number of Prussian blue stain-positive cells per high power field (r = 0.98, p < 0.05). Conclusion: Intraarterial injected SPIO-labeled MSCs in an experimental rat model of renal ischemia can be detected with the use of in vivo MR imaging immediately after injection. | ko_KR |
dc.description.sponsorship | This study was partly supported by a grant from the
Seoul Research and Business Development Program 10548 and by a grant (A062260) from the Innovative Research Institute for Cell Therapy, Republic of Korea. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN RADIOLOGICAL SOC | ko_KR |
dc.subject | Mesenchymal stem cell | ko_KR |
dc.subject | Kidney, ischemia | ko_KR |
dc.subject | Superparamagnetic iron oxide, MR | ko_KR |
dc.title | In Vivo MR Imaging of Magnetically Labeled Mesenchymal Stem Cells in a Rat Model of Renal Ischemia | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 정성일 | - |
dc.contributor.AlternativeAuthor | 김승협 | - |
dc.contributor.AlternativeAuthor | 김효철 | - |
dc.contributor.AlternativeAuthor | 손규리 | - |
dc.contributor.AlternativeAuthor | 정세영 | - |
dc.contributor.AlternativeAuthor | 문우경 | - |
dc.contributor.AlternativeAuthor | 김회석 | - |
dc.contributor.AlternativeAuthor | 최종선 | - |
dc.contributor.AlternativeAuthor | 문민환 | - |
dc.contributor.AlternativeAuthor | 성창규 | - |
dc.identifier.doi | 10.3348/kjr.2009.10.3.277 | - |
dc.citation.journaltitle | KOREAN JOURNAL OF RADIOLOGY | - |
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dc.description.tc | 2 | - |
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