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Inhibition of Double-Stranded RNA-Induced Inducible Nitric Oxide Synthase Expression by Fraxinellone and Sauchinone in Murine Microglia
DC Field | Value | Language |
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dc.contributor.author | Lee, Chang-Seok | - |
dc.contributor.author | Won, Cheolhee | - |
dc.contributor.author | Yoo, Hyouna | - |
dc.contributor.author | Yi, Eun Hee | - |
dc.contributor.author | Maeng, Jung Woo | - |
dc.contributor.author | Ye, Sang-Kyu | - |
dc.contributor.author | Chung, Myung-Hee | - |
dc.contributor.author | Sung, Sang Hyun | - |
dc.contributor.author | Cho, Yuri | - |
dc.date.accessioned | 2012-07-02T06:13:20Z | - |
dc.date.available | 2012-07-02T06:13:20Z | - |
dc.date.issued | 2009-11 | - |
dc.identifier.citation | BIOLOGICAL & PHARMACEUTICAL BULLETIN; Vol.32 11; 1870-1874 | ko_KR |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78095 | - |
dc.description.abstract | Fraxinellone and sauchinone, isolated from natural substance, are known to have an anti-inflammatory effect in inflammatory conditions. However, the anti-inflammatory actions of these compounds have been insufficiently demonstrated in viral-induced neuroinflammation. A viral component (double-stranded (ds)RNA) triggers a toll-like receptor 3-dependent inflammatory response that stimulates pro-inflammatory mediators in the brain. In present study, we initially examined the biological effects of fraxinellone and sauchinone on anti-inflammatory actions in dsRNA-stimulated microglia. Both compounds inhibited dsRNA-induced inducible nitric oxide synthase (NOS) expression, a major pro-inflammatory enzyme. 16 demonstrate the mechanism of inhibitory effect on NOS expression, we further examined file signaling pathway induced by dsRNA in microglia. Our data show that dsRNA promotes the expression of signal transducers and activators of transcription (STAT)1/3 identified as major inflammatory transcription factors as well as activates c-Jun N-terminal kinase (JNK) in an early time. Moreover, both compounds suppressed activation of JNK-STAT1/3 signaling pathway. These results suggest that an anti-inflammatory effect by fraxinellone and sauchinone is mediated via blockade of the JNK-STAT1/3-iNOS signaling pathway in viral-infected microglia. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | PHARMACEUTICAL SOC JAPAN | ko_KR |
dc.subject | double-stranded RNA | ko_KR |
dc.subject | inducible nitric oxide synthase, STAT, c-Jun N-terminal kinase, fraxinellone, sauchinone | ko_KR |
dc.subject | STAT | ko_KR |
dc.subject | c-Jun N-terminal kinase | ko_KR |
dc.title | Inhibition of Double-Stranded RNA-Induced Inducible Nitric Oxide Synthase Expression by Fraxinellone and Sauchinone in Murine Microglia | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이창석 | - |
dc.contributor.AlternativeAuthor | 원철희 | - |
dc.contributor.AlternativeAuthor | 유현아 | - |
dc.contributor.AlternativeAuthor | 이은희 | - |
dc.contributor.AlternativeAuthor | 조유리 | - |
dc.contributor.AlternativeAuthor | 맹정우 | - |
dc.contributor.AlternativeAuthor | 성상현 | - |
dc.contributor.AlternativeAuthor | 예상규 | - |
dc.contributor.AlternativeAuthor | 정명희 | - |
dc.identifier.doi | 10.1248/bpb.32.1870 | - |
dc.citation.journaltitle | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.description.citedreference | Huang CF, 2008, J NEUROIMMUNOL, V204, P118, DOI 10.1016/j.jneuroim.2008.07.004 | - |
dc.description.citedreference | O`Shea JJ, 2008, IMMUNITY, V28, P477, DOI 10.1016/j.immuni.2008.03.002 | - |
dc.description.citedreference | Kong PJ, 2008, NEUROSCI LETT, V433, P215, DOI 10.1016/j.neulet.2007.10.052 | - |
dc.description.citedreference | Yoon JS, 2008, J NAT PROD, V71, P208, DOI 10.1021/np070588o | - |
dc.description.citedreference | Liu P, 2007, J VIROL, V81, P1401, DOI 10.1128/JVI.01740-06 | - |
dc.description.citedreference | NAKAMICHI K, 2007, NEUROSCI LETT, V13, P222 | - |
dc.description.citedreference | Planas AM, 2006, BIOCHEM SOC T, V34, P1267 | - |
dc.description.citedreference | Kim HS, 2006, FREE RADICAL BIO MED, V41, P1392, DOI 10.1016/j.freerbiomed.2006.07.018 | - |
dc.description.citedreference | Town T, 2006, J IMMUNOL, V176, P3804 | - |
dc.description.citedreference | Chen JC, 2005, EUR J PHARMACOL, V521, P9, DOI 10.1016/j.ejphar.2005.08.005 | - |
dc.description.citedreference | de Prati AC, 2005, CURR MED CHEM, V12, P1819 | - |
dc.description.citedreference | Malmgaard L, 2004, J INTERF CYTOK RES, V24, P439 | - |
dc.description.citedreference | Hwang BY, 2003, PLANTA MED, V69, P1096, DOI 10.1055/s-2003-45189 | - |
dc.description.citedreference | Kleinert H, 2003, BIOL CHEM, V384, P1343 | - |
dc.description.citedreference | Song H, 2003, BIOL PHARM BULL, V26, P1428, DOI 10.1248/bpb.26.1428 | - |
dc.description.citedreference | Lee AK, 2003, BRIT J PHARMACOL, V139, P11, DOI 10.1038/sj.bjp.0705231 | - |
dc.description.citedreference | Peters KL, 2002, P NATL ACAD SCI USA, V99, P6322, DOI 10.1073/pnas.092133199 | - |
dc.description.citedreference | Mogensen TH, 2001, MICROBIOL MOL BIOL R, V65, P131 | - |
dc.description.citedreference | Sung SH, 2000, J NAT PROD, V63, P1019, DOI 10.1021/np990499e | - |
dc.description.citedreference | Kreutzberg GW, 1996, TRENDS NEUROSCI, V19, P312 | - |
dc.description.tc | 1 | - |
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