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Increased CA 19-9 level in patients without malignant disease

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dc.contributor.authorKim, Hye-Ryoun-
dc.contributor.authorLee, Chang-Hyun-
dc.contributor.authorKim, Young Whan-
dc.contributor.authorHan, Sung Koo-
dc.contributor.authorYim, Jae-Joon-
dc.contributor.authorShim, Young-Soo-
dc.date.accessioned2012-07-02T06:26:01Z-
dc.date.available2012-07-02T06:26:01Z-
dc.date.issued2009-06-
dc.identifier.citationCLINICAL CHEMISTRY AND LABORATORY MEDICINE; Vol.47 6; 750-754ko_KR
dc.identifier.issn1434-6621-
dc.identifier.urihttps://hdl.handle.net/10371/78099-
dc.description.abstractBackground: The measurement of carbohydrate antigen 19-9 (CA 19-9) is recommended for the diagnosis and follow-up of pancreatic cancer. However, increased CA 19-9 has also been reported in patients with various benign diseases of the lung. We aimed to elucidate the pulmonary radiographic abnormalities and laboratory results associated with increased concentrations of CA 19-9. Methods: This study was performed using a case-controlled design. Cases included all participants in a cancer screening program who had an increased CA 19-9 concentration (> 37 U/mL), but without a diagnosis of malignancy. Age- and sex-matched participants with normal CA 19-9 levels were enrolled as controls. Laboratory results and radiographic features were compared. Results: In total, 119 participants with increased CA 19-9 concentrations and 476 controls were included. A higher erythrocyte sedimentation rate (ESR) [adjusted odd ratio (aOR), 1.03; 95% confidence interval (CI), 1.01-1.05], higher hemoglobin A(1c) (HbA(1c)) (aOR, 1.28; 95% CI, 1.05-1.56), bronchiectasis (aOR, 2.48; 95% CI, 1.22-5.02), bronchiolitis (aOR, 3.93; 95% CI, 1.88-8.22), emphysema (aOR, 2.67; 95% CI, 1.32-5.40), and interstitial fibrosis (aOR, 10.62; 95% CI, 2.03-55.44) were independent factors for increased CA 19-9. Conclusions: CA 19-9 concentrations, as well as increased ESR and HbA(1c), can be increased in patients with various lung abnormalities.ko_KR
dc.language.isoenko_KR
dc.publisherWALTER DE GRUYTER & COko_KR
dc.subjectbronchiectasisko_KR
dc.subjectpulmonary fibrosisko_KR
dc.subjectemphysemako_KR
dc.subjectbronchiolitisko_KR
dc.subjectcarbohydrate antigen 19-9 (CA 19-9) antigenko_KR
dc.titleIncreased CA 19-9 level in patients without malignant diseaseko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김혜련-
dc.contributor.AlternativeAuthor이창현-
dc.contributor.AlternativeAuthor김영환-
dc.contributor.AlternativeAuthor한성구-
dc.contributor.AlternativeAuthor심영수-
dc.contributor.AlternativeAuthor임재준-
dc.identifier.doi10.1515/CCLM.2009.152-
dc.citation.journaltitleCLINICAL CHEMISTRY AND LABORATORY MEDICINE-
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College of Medicine/School of Medicine (의과대학/대학원)Radiology (영상의학전공)Journal Papers (저널논문_영상의학전공)
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