Browse

The Antitumor Effect and Hepatotoxicity of a Hexokinase II Inhibitor 3-Bromopyruvate: In Vivo Investigation of Intraarterial Administration in a Rabbit VX2 Hepatoma Model

DC Field Value Language
dc.contributor.authorJae, Hwan Jun-
dc.contributor.authorChung, Jin Wook-
dc.contributor.authorPark, Hee Sun-
dc.contributor.authorLee, Min Jong-
dc.contributor.authorKim, Hyo-Cheol-
dc.contributor.authorChung, Hesson-
dc.contributor.authorPark, Jae Hyung-
dc.contributor.authorYoon, Jung Hwan-
dc.contributor.authorLee, Ki Chang-
dc.date.accessioned2012-07-02T07:47:31Z-
dc.date.available2012-07-02T07:47:31Z-
dc.date.issued2009-12-
dc.identifier.citationKOREAN JOURNAL OF RADIOLOGY; Vol.10 6; 596-603ko_KR
dc.identifier.issn1229-6929-
dc.identifier.urihttps://hdl.handle.net/10371/78118-
dc.description.abstractObjective: The purpose of this study was to compare the antitumor effect and hepatotoxicity of an intraarterial delivery of low-dose and high-dose 3-bromopyruvate (3-BrPA) and those of a conventional Lipiodol-doxorubicin emulsion in a rabbit VX2 hepatoma model. Materials and Methods: This experiment was approved by the animal care committee at our institution. VX2 carcinoma was implanted in the livers of 36 rabbits. Transcatheter intraarterial administration was performed using low dose 3-BrPA (25 mL in a 1 mM concentration, n = 10), high dose 3-BrPA (25 mL in a 5 mM concentration, n = 10) and Lipiodol-doxorubicin emulsion (1.6 mg doxorubicin/0.4 mL Lipiodol, n = 10), and six rabbits were treated with normal saline alone as a control group. One week later, the proportion of tumor necrosis was calculated based on histopathologic examination. The hepatotoxicity was evaluated by biochemical analysis. The differences between these groups were statistically assessed with using Mann-Whitney U tests and Kruskal-Wallis tests. Results: The tumor necrosis rate was significantly higher in the high dose group (93% +/- 7.6 [mean +/- SD]) than that in the control group (48% +/- 21.7) (p = 0.0002), but the tumor necrosis rate was not significantly higher in the low dose group (62% +/- 20.0) (p = 0.2780). However, the tumor necrosis rate of the high dose group was significantly lower than that of the Lipiodol-doxorubicin treatment group (99% +/- 2.7) (p = 0.0015). The hepatotoxicity observed in the 3-BrPA groups was comparable to that of the Lipiodol-doxorubicin group. Conclusion: Even though intraarterial delivery of 3-BrPA shows a dose-related antitumor effect, single session treatment seems to have limited efficacy when compared with the conventional method.ko_KR
dc.language.isoenko_KR
dc.publisherKOREAN RADIOLOGICAL SOCko_KR
dc.subjectHepatocellular carcinomako_KR
dc.subject3-Bromopyruvateko_KR
dc.subjectVX2 carcinomako_KR
dc.subjectIntraarterial chemotherapyko_KR
dc.subjectHexokinase II inhibitorko_KR
dc.titleThe Antitumor Effect and Hepatotoxicity of a Hexokinase II Inhibitor 3-Bromopyruvate: In Vivo Investigation of Intraarterial Administration in a Rabbit VX2 Hepatoma Modelko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor재환준-
dc.contributor.AlternativeAuthor정진욱-
dc.contributor.AlternativeAuthor박희선-
dc.contributor.AlternativeAuthor이민종-
dc.contributor.AlternativeAuthor이기창-
dc.contributor.AlternativeAuthor김효철-
dc.contributor.AlternativeAuthor윤정환-
dc.contributor.AlternativeAuthor정혜선-
dc.contributor.AlternativeAuthor박재형-
dc.identifier.doi10.3348/kjr.2009.10.6.596-
dc.citation.journaltitleKOREAN JOURNAL OF RADIOLOGY-
dc.description.citedreferenceVali M, 2008, J PHARMACOL EXP THER, V327, P32, DOI 10.1124/jpet.108.141093-
dc.description.citedreferencePark HS, 2007, KOREAN J RADIOL, V8, P216-
dc.description.citedreferenceVali M, 2007, J VASC INTERV RADIOL, V18, P95, DOI 10.1016/j.jvir.2006.10.019-
dc.description.citedreferenceShin SW, 2006, ACTA RADIOL, V47, P1036, DOI 10.1080/02841850600977752-
dc.description.citedreferenceGwak GY, 2005, J HEPATOL, V42, P358, DOI 10.1016/j.jhep.2004.11.020-
dc.description.citedreferenceKo YH, 2004, BIOCHEM BIOPH RES CO, V324, P269, DOI 10.1016/j.bbrc.2004.09.047-
dc.description.citedreferenceLlovet JM, 2003, LANCET, V362, P1907-
dc.description.citedreferenceYoon CJ, 2003, RADIOLOGY, V229, P126, DOI 10.1148/radio.2291021029-
dc.description.citedreferencePedersen PL, 2002, BBA-BIOENERGETICS, V1555, P14-
dc.description.citedreferenceGeschwind JFH, 2002, CANCER RES, V62, P3909-
dc.description.citedreferenceKo YH, 2001, CANCER LETT, V173, P83-
dc.description.citedreferenceSmith TAD, 2000, BRIT J BIOMED SCI, V57, P170-
dc.description.citedreferencePedersen PL, 1999, J BIOENERG BIOMEMBR, V31, P291-
dc.description.citedreferenceDang CV, 1999, TRENDS BIOCHEM SCI, V24, P68-
dc.description.citedreferenceBosch FX, 1999, SEMIN LIVER DIS, V19, P271-
dc.description.citedreferenceBruix J, 1997, HEPATOLOGY, V25, P259-
dc.description.citedreferenceRempel A, 1996, CANCER RES, V56, P2468-
dc.description.citedreferenceStuart KE, 1996, CANCER, V77, P2217-
dc.description.citedreferenceMATHUPALA SP, 1995, J BIOL CHEM, V270, P16918-
dc.description.citedreferenceOKADA M, 1995, BRIT J CANCER, V71, P518-
dc.description.citedreferenceWATANABE D, 1995, ONCOLOGY, V52, P76-
dc.description.citedreferenceREMPEL A, 1994, BBA-GENE STRUCT EXPR, V1219, P660-
dc.description.citedreferenceBRUIX J, 1992, J HEPATOL, V15, P350-
dc.description.citedreferenceOKUDA K, 1992, HEPATOLOGY, V15, P948-
dc.description.citedreferenceSHINOHARA Y, 1991, FEBS LETT, V291, P55-
dc.description.citedreferenceKO YH, 1990, ARCH BIOCHEM BIOPHYS, V278, P373-
dc.description.citedreferenceBISMUTH H, 1986, WORLD J SURG, V10, P311-
dc.description.citedreferenceJOHANSSON T, 1985, BIOCHEM BIOPH RES CO, V133, P608-
dc.description.citedreferenceVIITANEN PV, 1984, J BIOL CHEM, V259, P9679-
dc.description.citedreferenceBUSTAMANTE E, 1981, J BIOL CHEM, V256, P8699-
dc.description.citedreferencePEDERSEN PL, 1978, PROGR EXPT TUMOR RES, V22, P190-
dc.description.citedreferenceWEINHOUS.S, 1972, CANCER RES, V32, P2007-
dc.description.tc2-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Radiology (영상의학전공)Journal Papers (저널논문_영상의학전공)
Files in This Item:
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse