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High-Resolution Diffusion Tensor MR Imaging for Evaluating Myocardial Anisotropy and Fiber Tracking at 3T: the Effect of the Number of Diffusion-Sensitizing Gradient Directions

Cited 3 time in Web of Science Cited 5 time in Scopus
Authors

Choi, Sang Il; Kang, Joon-Won; Chun, Eun Ju; Choi, Seong Hoon; Lim, Tae-Hwan

Issue Date
2010-02
Publisher
KOREAN RADIOLOGICAL SOC
Citation
KOREAN JOURNAL OF RADIOLOGY; Vol.11 1; 54-59
Keywords
Diffusion tensorMyocardiumMagnetic resonance (MR)
Abstract
Objective: We wanted to evaluate the effect of the number of diffusion-sensitizing gradient directions on the image quality for evaluating myocardial anisotropy and fiber tracking by using in vitro diffusion tensor MR imaging (DT-MRI). Materials and Methods: The DT-MR images, using a SENSE-based echo-planar imaging technique, were acquired from ten excised porcine hearts by using a 3T MR scanner. With a b-value of 800 S/mm(2), the diffusion tensor images were obtained for 6,15 and 32 diffusion-sensitizing gradient directions at the mid-ventricular level. The number of tracked fibers, the fractional anisotropy (FA), and the length of the tracked fibers were measured for the quantitative analysis. Two radiologists assessed the image quality of the fiber tractography for the qualitative analysis. Results: By increasing the number of diffusion-sensitizing gradient directions from 6 to 15, and then to 32, the FA and standard deviation were significantly reduced (p < 0.01), and the number of tracked fibers and the length of the tracked fibers were significantly increased (p < 0.01). The image quality of the fiber tractography was significantly increased with the increased number of diffusion-sensitizing gradient directions (p < 0.01). Conclusion: The image quality of in vitro DT-MRI is significantly improved as the number of diffusion-sensitizing gradient directions is increased.
ISSN
1229-6929
Language
English
URI
https://hdl.handle.net/10371/78132
DOI
https://doi.org/10.3348/kjr.2010.11.1.54
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