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BT-11 Improves Stress-Induced Memory Impairments Through Increment of Glucose Utilization and Total Neural Cell Adhesion Molecule Levels in Rat Brains

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dc.contributor.authorShin, Ki Young-
dc.contributor.authorWon, Beom Young-
dc.contributor.authorHeo, Chaejeong-
dc.contributor.authorKim, Hee Jin-
dc.contributor.authorPark, Cheol Hyoung-
dc.contributor.authorKim, Hye-Sun-
dc.contributor.authorLee, Hyung Gun-
dc.contributor.authorCho, Zang-Hee-
dc.contributor.authorSuh, Yoo-Hun-
dc.contributor.authorLee, Sang Hyung-
dc.contributor.authorKim, Young-Bo-
dc.contributor.authorKim, Seonghan-
dc.contributor.authorJang, Dong-Pyo-
dc.date.accessioned2012-07-03T00:44:50Z-
dc.date.available2012-07-03T00:44:50Z-
dc.date.issued2009-01-
dc.identifier.citationJOURNAL OF NEUROSCIENCE RESEARCH; Vol.87 1; 260-268ko_KR
dc.identifier.issn0360-4012-
dc.identifier.urihttps://hdl.handle.net/10371/78161-
dc.description.abstractIn Oriental medicine, roots of Polygala tenuifolia Willde-now have been known to be an important herb that exhibits sedative effects in insomnia, palpitation with anxiety, restlessness, and disorientation in humans. We previously reported that BT-11, extracted from those roots, improved scopolamine-induced amnesia in rats and inhibited acetylcholinesterase activities in vitro. Therefore, we proposed that BT-11 could remedy stress-induced memory deficits in rats. In this study, the stress-induced memory impairments in rats were significantly reversed almost to the control level by BT-11 treatment. To seek an active component of BT-11 that plays an important role in antipsychotic effects, we compared BT-11 with 3,4,5-trimethoxycinnamic acid (TMCA), which is a constituent of those root extracts. However, the effects of TMCA were less or were not consistent with those of BT-11 in some of tests. In perticular, BT-11 reversed the stress-induced reduction of glucose utilization by [(18)fluorodeoxyglucose] FDG-PET and the levels of neural cell adhesion molecule (NCAM) in rat brains to the control levels, whereas TMCA did not. Therefore, BT-11 improved stress-induced memory impairments through increment of glucose utilization and total NCAM levels in rat brains. In conclusion, BT-11 may be strongly effective against stress-induced amnesia in rats, through the combined effects of TMCA and other active components of BT-11. (C) 2008 Wiley-Liss, Inc.ko_KR
dc.language.isoenko_KR
dc.publisherWILEY-LISSko_KR
dc.subjectBT-11ko_KR
dc.subjectmemoryko_KR
dc.subjectstressko_KR
dc.subject3,4,5-trimethoxycinnamic acidko_KR
dc.subjectPolygala tenuifoliako_KR
dc.titleBT-11 Improves Stress-Induced Memory Impairments Through Increment of Glucose Utilization and Total Neural Cell Adhesion Molecule Levels in Rat Brainsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor신기영-
dc.contributor.AlternativeAuthor원범영-
dc.contributor.AlternativeAuthor허채정-
dc.contributor.AlternativeAuthor김희진-
dc.contributor.AlternativeAuthor장동표-
dc.contributor.AlternativeAuthor박철형-
dc.contributor.AlternativeAuthor김성한-
dc.contributor.AlternativeAuthor김혜선-
dc.contributor.AlternativeAuthor김영보-
dc.contributor.AlternativeAuthor이형군-
dc.contributor.AlternativeAuthor이상형-
dc.contributor.AlternativeAuthor조장희-
dc.contributor.AlternativeAuthor서유헌-
dc.identifier.doi10.1002/jnr.21834-
dc.citation.journaltitleJOURNAL OF NEUROSCIENCE RESEARCH-
dc.description.citedreferenceTsoory M, 2008, NEUROPSYCHOPHARMACOL, V33, P378, DOI 10.1038/sj.npp.1301397-
dc.description.citedreferenceGarcia-Bueno B, 2007, NEUROPSYCHOPHARMACOL, V32, P1251, DOI 10.1038/sj.npp.1301252-
dc.description.citedreferenceWilson RS, 2007, PSYCHOSOM MED, V69, P47, DOI 10.1097/01.psy.0000250264.25017.21-
dc.description.citedreferenceWesolowska A, 2006, EUR J PHARMACOL, V553, P185, DOI 10.1016/j.ejphar.2006.09.064-
dc.description.citedreferenceFrassetto SS, 2006, CAN J PHYSIOL PHARM, V84, P1239, DOI 10.1139/Y06-082-
dc.description.citedreferenceKleen JK, 2006, BEHAV NEUROSCI, V120, P842, DOI 10.1037/0735-7044.120.4.842-
dc.description.citedreferenceWright RL, 2006, EUR J NEUROSCI, V24, P595, DOI 10.1111/j.1460-9568.2006.04948.x-
dc.description.citedreferenceTeipel SJ, 2006, PSYCHOPHARMACOLOGY, V187, P86, DOI 10.1007/s00213-006-0408-1-
dc.description.citedreferenceFueger BJ, 2006, J NUCL MED, V47, P999-
dc.description.citedreferenceFreo U, 2005, AM J PSYCHIAT, V162, P2061-
dc.description.citedreferencePereira P, 2005, PHARMACOL RES, V52, P199, DOI 10.1016/j.phrs.2005.03.003-
dc.description.citedreferenceSandi C, 2005, BIOL PSYCHIAT, V57, P856, DOI 10.1016/j.biopsych.2004.12.034-
dc.description.citedreferenceSandi C, 2004, NAT REV NEUROSCI, V5, P917, DOI 10.1038/nrn1555-
dc.description.citedreferenceJia HX, 2004, NEUROSCI LETT, V367, P123, DOI 10.1016/j.neulet.2004.05.093-
dc.description.citedreferenceKawashima K, 2004, BIOL PHARM BULL, V27, P1317, DOI 10.1248/bpb.27.1317-
dc.description.citedreferenceIkeya Y, 2004, BIOL PHARM BULL, V27, P1081, DOI 10.1248/bpb.27.1081-
dc.description.citedreferenceDong H, 2004, NEUROSCIENCE, V127, P601, DOI 10.1016/j.neuroscience.2004.05.040-
dc.description.citedreferenceShah ZA, 2003, EUR NEUROPSYCHOPHARM, V13, P321, DOI 10.1016/S0924-977X(03)00005-1-
dc.description.citedreferenceKoo JW, 2003, FASEB J, V17, P1556, DOI 10.1096/fj.02-1032fje-
dc.description.citedreferenceMizoguchi K, 2003, PHARMACOL BIOCHEM BE, V75, P419, DOI 10.1016/S0091-3057(03)00131-X-
dc.description.citedreferenceRoozendaal B, 2002, NEUROBIOL LEARN MEM, V78, P578, DOI 10.1006/nlme.2002.4080-
dc.description.citedreferencePark CH, 2002, J NEUROSCI RES, V70, P484, DOI 10.1002/jnr.10429-
dc.description.citedreferenceChung IW, 2002, PHARMACOL BIOCHEM BE, V71, P191-
dc.description.citedreferenceKiss JZ, 2001, BRAIN RES REV, V36, P175-
dc.description.citedreferenceKornblum HI, 2000, NAT BIOTECHNOL, V18, P655-
dc.description.citedreferencePark CH, 2000, J NEUROCHEM, V74, P244-
dc.description.citedreferenceNewcomer JW, 1999, ARCH GEN PSYCHIAT, V56, P527-
dc.description.citedreferenceNewcomer JW, 1998, PSYCHONEUROENDOCRINO, V23, P65-
dc.description.citedreferenceMuller RA, 1998, J CHILD NEUROL, V13, P16-
dc.description.citedreferenceSchachner M, 1997, CURR OPIN CELL BIOL, V9, P627-
dc.description.citedreferenceBergsneider M, 1997, J NEUROSURG, V86, P241-
dc.description.citedreferenceCremer H, 1997, MOL CELL NEUROSCI, V8, P323-
dc.description.citedreferenceIglesias S, 1996, STROKE, V27, P1192-
dc.description.citedreferenceMAHER F, 1995, J NEUROSCI RES, V42, P459-
dc.description.citedreferenceBRUEHL C, 1995, ANN NEUROL, V38, P414-
dc.description.citedreferenceHATZINGER M, 1995, NEUROBIOL AGING, V16, P205-
dc.description.citedreferenceMAZURE CM, 1995, PROGR PSYCHIAT, P270-
dc.description.citedreferenceCHUGANI HT, 1994, ANN NEUROL, V36, P794-
dc.description.citedreferenceHUANG KC, 1993, PHARM CHINESE HERBS-
dc.description.citedreferenceCHUGANI HT, 1991, J CEREBR BLOOD F MET, V11, P35-
dc.description.citedreferenceSARTER M, 1988, PSYCHOPHARMACOLOGY, V94, P491-
dc.description.citedreferenceREUS VI, 1984, DRUG DEVELOP RES, V4, P489-
dc.description.citedreferenceCOHEN RM, 1982, ARCH GEN PSYCHIAT, V39, P593-
dc.description.citedreferenceGREER CA, 1981, BRAIN RES, V217, P279-
dc.description.citedreferenceSCHWARTZ WJ, 1979, SCIENCE, V205, P723-
dc.description.tc15-
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College of Medicine/School of Medicine (의과대학/대학원)Pharmacology (약리학전공)Journal Papers (저널논문_약리학전공)
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