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Cathepsin G increases MMP expression in normal human fibroblasts through fibronectin fragmentation, and induces the conversion of proMMP-1 to active MMP-1

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dc.contributor.authorSon, Eui Dong-
dc.contributor.authorKim, Hyaekyoung-
dc.contributor.authorChi, Hyunjung-
dc.contributor.authorLee, So Hee-
dc.contributor.authorKim, Sujung-
dc.contributor.authorLee, Sera-
dc.contributor.authorHwang, Jae Sung-
dc.contributor.authorChung, Jin Ho-
dc.contributor.authorCloss, B.-
dc.contributor.authorLee, Jin Young-
dc.date.accessioned2012-07-03T01:44:32Z-
dc.date.available2012-07-03T01:44:32Z-
dc.date.issued2009-02-
dc.identifier.citationJOURNAL OF DERMATOLOGICAL SCIENCE; Vol.53(2); 150-152ko_KR
dc.identifier.issn0923-1811-
dc.identifier.urihttp://hdl.handle.net/10371/78179-
dc.description.abstractFibronectin (Fn) is a glycoprotein that is found in the plasma
and is a component of the extracellular matrix (ECM). It binds to
collagen and fibulin, as well as a class of the cell surface
adhesion receptors termed integrins, and has been shown to be
involved in various biological activities, including cell attachment,
cell migration, and wound healing [1]. Fn is readily
degraded into fibronectin fragment (Fn-frs) through the action
of many different types of proteases [2] containing cathepsin G
[3]. The expression of MMP (matrix metalloproteinase) by Fn-frs
(Fn-f29; N-terminal heparin binding fragment, 45 kDa; Fn-f45,
collagen binding fragment, and 110 kDa; Fn-f110 cell binding
fragment) has been studied in chondrocytes [4–6], however,
little is known about the roles of Fn-frs, or cathepsin G-mediated
fragmentation of Fn, in aged human skin and normal human
fibroblasts (NHFs).
ko_KR
dc.language.isoenko_KR
dc.publisherELSEVIER IRELAND LTDko_KR
dc.subjectFibronectinko_KR
dc.subjectExtracellular matrixko_KR
dc.subjectCathepsin Gko_KR
dc.subjectSkin agingko_KR
dc.subjectFibronectin fragmentsko_KR
dc.titleCathepsin G increases MMP expression in normal human fibroblasts through fibronectin fragmentation, and induces the conversion of proMMP-1 to active MMP-1ko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor손의동-
dc.contributor.AlternativeAuthor김혜경-
dc.contributor.AlternativeAuthor지현정-
dc.contributor.AlternativeAuthor이소희-
dc.contributor.AlternativeAuthor이진영-
dc.contributor.AlternativeAuthor김수정-
dc.contributor.AlternativeAuthor이세라-
dc.contributor.AlternativeAuthor정진호-
dc.contributor.AlternativeAuthor황재성-
dc.identifier.doi10.1016/j.jdermsci.2008.08.006-
dc.citation.journaltitleJOURNAL OF DERMATOLOGICAL SCIENCE-
dc.description.citedreferenceLoeser RF, 2003, J BIOL CHEM, V278, P24577, DOI 10.1074/jbc.M304530200-
dc.description.citedreferenceLabat-Robert J, 2002, SEMIN CANCER BIOL, V12, P187, DOI 10.1016/S1044-579X(02)00022-6-
dc.description.citedreferenceStanton H, 2002, BIOCHEM J, V364, P181-
dc.description.citedreferenceHomandberg GA, 1998, OSTEOARTHR CARTILAGE, V6, P231-
dc.description.citedreferenceXIE DL, 1994, ARCH BIOCHEM BIOPHYS, V311, P205-
dc.description.citedreferenceHYNES RO, 1990, FIBRONECTINS-
dc.description.citedreferenceVARTIO T, 1982, EUR J BIOCHEM, V123, P223-
dc.description.citedreferenceFYRAND O, 1981, DERMATOLOGICA, V162, P220-
dc.description.tc2-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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