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Clinical efficacies of topical agents for the treatment of seborrheic dermatitis of the scalp: A comparative study

Cited 18 time in Web of Science Cited 27 time in Scopus
Authors
Shin, Hyoseung; Kwon, Oh Sang; Won, Chong Hyun; Kim, Beom Joon; Choe, Yong Beom; Eun, Hee Chul; Ahn, Kyu Joong; Lee, Yang Won
Issue Date
2009-03
Publisher
WILEY-BLACKWELL PUBLISHING, INC
Citation
JOURNAL OF DERMATOLOGY; Vol.36(3); 131-137
Keywords
betamethasoneseborrheic dermatitistacrolimuszinc pyrithionetreatment
Abstract
Previous studies have shown that topical steroid and shampoo containing zinc pyrithione provide clinical benefits for treatment of scalp seborrheic dermatitis. But the clinical efficacy of topical tacrolimus, a newly developed calcineurin inhibitor on seborrheic dermatitis, is not well investigated yet. We wanted to compare the clinical efficacy of topical tacrolimus with that of conventional treatment (zinc pyrithione shampoo and topical betamethasone) for treatment of seborrheic dermatitis of the scalp. Patients with seborrheic dermatitis of the scalp were randomly allocated to receive topical betamethasone, topical tacrolimus or zinc pyrithione shampoo. Some patients were instructed to continue the treatments for 8 weeks and the others to discontinue the treatments at week 4. We evaluated the efficacy using a clinical severity score, dandruff score and sebum secretion at baseline, week 4 and week 8. All treatment groups showed significant improvements in clinical assessment after 4 weeks. While the patients treated by zinc pyrithione improved continuously even after cessation of the treatment, the patients treated by betamethasone lotion or tacrolimus ointment were aggravated clinically. Topical tacrolimus was as effective as topical betamethasone, and showed more prolonged remission than topical betamethasone. To treat seborrheic dermatitis of the scalp, we think that the combination therapy of topical steroid or topical tacrolimus, and zinc pyrithione is recommended.
ISSN
0385-2407
Language
English
URI
https://hdl.handle.net/10371/78185
DOI
https://doi.org/10.1111/j.1346-8138.2009.00607.x
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College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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