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THE EFFECT OF NMDA RECEPTOR ANTAGONIST TREATMENT ON ERK1/2-S6K-S6 SIGNAL PAHTWAY AND PROTEIN SYNTHESIS IN DEVELOPING RAT BRAIN

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Authors
Park, H. G.; Kim, S. H.; Yu, H. S.; Kim, M. K.; Kim, Y. S.; Yi, H. S.
Issue Date
2009-09
Publisher
WILEY-BLACKWELL PUBLISHING, INC
Citation
JOURNAL OF NEUROCHEMISTRY; Vol.110 ; 173-173
Abstract
Treatment of MK-801, a selective NMDA receptor antagonist, on
neonatal rat induces long-term neurochemical and behavioral
changes, which is suggested as neurodevelopmental rat model of
schizophrenia. Proper regulation of protein synthesis is required for
neurodevelopment process. Here, effects of MK-801 treatment at
PN7 on p70S6K and mTOR signal pathways related to protein
translation and protein synthesis rate were examined in frontal
cortex of developing rat brain. Single injection of MK-801, 0.5 and
1.0 mg/kg, induced significant decrease in the of phosphorylation of
p70S6K, S6, and eIF4B until 8 h. Two injections of MK-801 induced more prominent changes. These changes were accompanied
with changes in ERK1/2-p90RSK pathway along with Egr-1
expression, but not with AKT-mTOR pathway. Moreover, two
injections of MK-801, 1.0 mg/kg, induced significant decrease in
protein synthesis rate at 8 h, which was measured by [3H] leucin
incorporation. In addition, MK-801 treatments at PN7 induced
increase in locomotor activity and deficits in prepulse inhibition at
PN56. Taken together, neonatal treatment of MK-801 induces
dysregulation in ERK1/2-p70S6K-S6 pathway and protein synthesis
rate in frontal cortex of developing rat brain with long-term
behavioral changes.
ISSN
0022-3042
Language
English
URI
https://hdl.handle.net/10371/78187
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Journal Papers (저널논문_의학과)
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