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Copper-GHK increases integrin expression and p63 positivity by keratinocytes

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dc.contributor.authorKang, Youn-A-
dc.contributor.authorChoi, Hye-Ryung-
dc.contributor.authorNa, Jung-Im-
dc.contributor.authorHuh, Chang-Hun-
dc.contributor.authorYoun, Sang-Woong-
dc.contributor.authorPark, Kyoung-Chan-
dc.contributor.authorKim, Kyu-Han-
dc.contributor.authorKim, Min-Ji-
dc.date.accessioned2012-07-03T04:16:41Z-
dc.date.available2012-07-03T04:16:41Z-
dc.date.issued2009-05-
dc.identifier.citationARCHIVES OF DERMATOLOGICAL RESEARCH; Vol.301, no.4; 301-306ko_KR
dc.identifier.issn0340-3696-
dc.identifier.urihttps://hdl.handle.net/10371/78206-
dc.description.abstractGlycyl-l-histidyl-l-lysyl (GHK) possesses a high affinity for copper(II) ions, with which it spontaneously forms a complex (copper-GHK). It is well known that copper-GHK plays a physiological role in the process of wound healing and tissue repair by stimulating collagen synthesis in fibroblasts. This study was conducted to investigate the effects of copper-GHK on keratinocytes. Proliferative effects were analyzed and hematoxylin and eosin staining and immunohistochemistry were conducted to evaluate the effects of copper-GHK in skin equivalent (SE) models. In addition, western blotting was performed. In monolayer cultured keratinocytes, copper-GHK increased the proliferation of keratinocytes. When the SE models were evaluated, basal cells became cuboidal when copper-GHK was added. Immunohistochemical analysis revealed that copper-GHK increased proliferating cell nuclear antigen (PCNA) and p63 positivity. Furthermore, the expression of integrin alpha 6 and beta 1 increased in SE models, and these results were confirmed by Western blotting. The results of this study indicate that treatment with copper-GHK may increase the proliferative potential of basal keratinocytes by modulating the expression of integrins, p63 and PCNA. In addition, increased levels of p63, a putative stem cell marker of the skin, suggests that copper-GHK promotes the survival of basal stem cells in the skin.ko_KR
dc.language.isoenko_KR
dc.publisherSPRINGERko_KR
dc.subjectPeptideko_KR
dc.subjectSkin equivalentsko_KR
dc.subjectIntegrinko_KR
dc.subjectStem cellsko_KR
dc.subjectp63ko_KR
dc.subjectCopper-GHKko_KR
dc.subjectKeratinocytesko_KR
dc.titleCopper-GHK increases integrin expression and p63 positivity by keratinocytesko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor강윤아-
dc.contributor.AlternativeAuthor최혜령-
dc.contributor.AlternativeAuthor나정임-
dc.contributor.AlternativeAuthor허창훈-
dc.contributor.AlternativeAuthor김민지-
dc.contributor.AlternativeAuthor윤상웅-
dc.contributor.AlternativeAuthor김규한-
dc.contributor.AlternativeAuthor박경찬-
dc.identifier.doi10.1007/s00403-009-0942-x-
dc.citation.journaltitleARCHIVES OF DERMATOLOGICAL RESEARCH-
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