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Copper-GHK increases integrin expression and p63 positivity by keratinocytes
DC Field | Value | Language |
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dc.contributor.author | Kang, Youn-A | - |
dc.contributor.author | Choi, Hye-Ryung | - |
dc.contributor.author | Na, Jung-Im | - |
dc.contributor.author | Huh, Chang-Hun | - |
dc.contributor.author | Youn, Sang-Woong | - |
dc.contributor.author | Park, Kyoung-Chan | - |
dc.contributor.author | Kim, Kyu-Han | - |
dc.contributor.author | Kim, Min-Ji | - |
dc.date.accessioned | 2012-07-03T04:16:41Z | - |
dc.date.available | 2012-07-03T04:16:41Z | - |
dc.date.issued | 2009-05 | - |
dc.identifier.citation | ARCHIVES OF DERMATOLOGICAL RESEARCH; Vol.301, no.4; 301-306 | ko_KR |
dc.identifier.issn | 0340-3696 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78206 | - |
dc.description.abstract | Glycyl-l-histidyl-l-lysyl (GHK) possesses a high affinity for copper(II) ions, with which it spontaneously forms a complex (copper-GHK). It is well known that copper-GHK plays a physiological role in the process of wound healing and tissue repair by stimulating collagen synthesis in fibroblasts. This study was conducted to investigate the effects of copper-GHK on keratinocytes. Proliferative effects were analyzed and hematoxylin and eosin staining and immunohistochemistry were conducted to evaluate the effects of copper-GHK in skin equivalent (SE) models. In addition, western blotting was performed. In monolayer cultured keratinocytes, copper-GHK increased the proliferation of keratinocytes. When the SE models were evaluated, basal cells became cuboidal when copper-GHK was added. Immunohistochemical analysis revealed that copper-GHK increased proliferating cell nuclear antigen (PCNA) and p63 positivity. Furthermore, the expression of integrin alpha 6 and beta 1 increased in SE models, and these results were confirmed by Western blotting. The results of this study indicate that treatment with copper-GHK may increase the proliferative potential of basal keratinocytes by modulating the expression of integrins, p63 and PCNA. In addition, increased levels of p63, a putative stem cell marker of the skin, suggests that copper-GHK promotes the survival of basal stem cells in the skin. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | SPRINGER | ko_KR |
dc.subject | Peptide | ko_KR |
dc.subject | Skin equivalents | ko_KR |
dc.subject | Integrin | ko_KR |
dc.subject | Stem cells | ko_KR |
dc.subject | p63 | ko_KR |
dc.subject | Copper-GHK | ko_KR |
dc.subject | Keratinocytes | ko_KR |
dc.title | Copper-GHK increases integrin expression and p63 positivity by keratinocytes | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 강윤아 | - |
dc.contributor.AlternativeAuthor | 최혜령 | - |
dc.contributor.AlternativeAuthor | 나정임 | - |
dc.contributor.AlternativeAuthor | 허창훈 | - |
dc.contributor.AlternativeAuthor | 김민지 | - |
dc.contributor.AlternativeAuthor | 윤상웅 | - |
dc.contributor.AlternativeAuthor | 김규한 | - |
dc.contributor.AlternativeAuthor | 박경찬 | - |
dc.identifier.doi | 10.1007/s00403-009-0942-x | - |
dc.citation.journaltitle | ARCHIVES OF DERMATOLOGICAL RESEARCH | - |
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dc.description.tc | 2 | - |
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