S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) Journal Papers (저널논문_의학과)
Xenoreactivity of human clonal mesenchymal stem cells in a major histocompatibility complex-matched allogeneic graft-versus-host disease mouse model
- Jeon, Myung-Shin; Lim, Hyun-Ja; Yi, Tac-Ghee; Im, Moon-Whan; Choi, Jung Hwa; Song, Sun U.; Choi, Eun-Young; Yoo, Hyun Seung
- Issue Date
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- CELLULAR IMMUNOLOGY; Vol.261 1; 57-63
- Effects of mesenchymal stem cells (MSCs) on graft-versus-host disease (GVHD) have been actively investigated since the discovery of the immunomodulation property of MSCs about a decade ago. Human clonal MSCs (hcMSCs) were isolated from human bone marrow aspirate according to our newly established isolation protocol called suffractionation culturing method, and were evaluated for their efficacy on GVHD treatment, using a mouse MHC-matched B6 -> BALB.B GVHD model system. Although the hcMSCs can suppress the allogeneic proliferation of human peripheral blood mononuclear cells in in vitro, the administration of the hcMSCs failed to reduce the GVHD-related mortality of the murine recipients. One of the reasons might be that murine cytokines such as IFN-gamma and TNF-alpha cannot activate the hcMSCs. Based on these results, we suggest that xenogeneic MSCs may not be used for the treatment of GVHD. (C) 2009 Elsevier Inc. All rights reserved.
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