Browse

Xenoreactivity of human clonal mesenchymal stem cells in a major histocompatibility complex-matched allogeneic graft-versus-host disease mouse model

Cited 11 time in Web of Science Cited 11 time in Scopus
Authors
Jeon, Myung-Shin; Lim, Hyun-Ja; Yi, Tac-Ghee; Im, Moon-Whan; Choi, Jung Hwa; Song, Sun U.; Choi, Eun-Young; Yoo, Hyun Seung
Issue Date
2010
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
CELLULAR IMMUNOLOGY; Vol.261 1; 57-63
Keywords
Clonal MSCGVHDIL-10T cellIDO
Abstract
Effects of mesenchymal stem cells (MSCs) on graft-versus-host disease (GVHD) have been actively investigated since the discovery of the immunomodulation property of MSCs about a decade ago. Human clonal MSCs (hcMSCs) were isolated from human bone marrow aspirate according to our newly established isolation protocol called suffractionation culturing method, and were evaluated for their efficacy on GVHD treatment, using a mouse MHC-matched B6 -> BALB.B GVHD model system. Although the hcMSCs can suppress the allogeneic proliferation of human peripheral blood mononuclear cells in in vitro, the administration of the hcMSCs failed to reduce the GVHD-related mortality of the murine recipients. One of the reasons might be that murine cytokines such as IFN-gamma and TNF-alpha cannot activate the hcMSCs. Based on these results, we suggest that xenogeneic MSCs may not be used for the treatment of GVHD. (C) 2009 Elsevier Inc. All rights reserved.
ISSN
0008-8749
Language
English
URI
http://hdl.handle.net/10371/78219
DOI
https://doi.org/10.1016/j.cellimm.2009.11.001
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Journal Papers (저널논문_의학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse