Publications
Detailed Information
A study of microRNAs in silico and in vivo
Cited 2 time in
Web of Science
Cited 6 time in Scopus
- Authors
- Issue Date
- 2009-04
- Publisher
- WILEY-BLACKWELL PUBLISHING, INC
- Citation
- FEBS JOURNAL; Vol.276 8; 2139-2139
- Abstract
- MicroRNAs (miRNAs) are a class of small noncoding
RNA molecules that account for 1% of the genome;
they are transcribed by RNA polymerase II in the
nucleus, processed into a single-stranded mature
miRNA of 19–25 nucleotides by the enzyme Dicer in
the cytoplasm, and then destabilize or inhibit the
translation of their target mRNAs in the genomes of
plants and animals. About 1000 miRNAs have been
identified by experimental and bioinformatic analysis
since the first miRNA, lin-4, was identified in Caenorhabditis
elegans in 1993. Recent evidence suggests that
the production of miRNAs is signal-specific and celltype
specific, and that miRNAs modulate the posttranscriptional
regulation of their targets in diverse
biological regulatory systems, including cell growth,
differentiation and cell death. In addition, miRNAs
are involved in the molecular mechanisms of diseases
such as cancers and diabetes. The miRNAs involved
in diseases have been a significant focus of attention in
work on miRNA–mRNA molecular networks and in
clinical reagents for imaging, diagnosis and the treatment
of disease. Many studies have identified and
described the biology of miRNAs at the molecular and
cellular levels. However, we are just beginning to
understand the expression of miRNAs and how they
regulate their targets in the development of disease.
- ISSN
- 1742-464X
- Language
- English
- Files in This Item:
- There are no files associated with this item.
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.