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In vitro Derby Imaging of Cancer Biomarkers Using Quantum Dots

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dc.contributor.authorKo, Mee Hyang-
dc.contributor.authorKim, Soonhag-
dc.contributor.authorKang, Won Jun-
dc.contributor.authorLee, Jung Hwan-
dc.contributor.authorMoon, Sung Hwan-
dc.contributor.authorKo, Hae Young-
dc.contributor.authorLee, Dong Soo-
dc.contributor.authorHwang, Do Won-
dc.contributor.authorKang, Hyungu-
dc.date.accessioned2012-07-03T06:00:24Z-
dc.date.available2012-07-03T06:00:24Z-
dc.date.issued2009-05-18-
dc.identifier.citationSMALL; Vol.5 10; 1207-1212ko_KR
dc.identifier.issn1613-6810-
dc.identifier.urihttps://hdl.handle.net/10371/78264-
dc.description.abstractSemiconductor quantum dots (QDs), which have broad absorption with narrow. emission spectra, are useful for multiplex imaging. Here, fluorescence derby imaging using dual color QDs conjugated by the AS1411 aptamer (targeting nucleolin) and the arginine-glycine-aspartic acid (targeting the integrin alpha(v)beta(3)) in cancer cells is reported. Simultaneous fluorescence imaging of cellular distribution of nucleolin and integrin alpha(v)beta(3) using QDs enables easy monitoring of separate targets in the cancer cells and the normal healthy cells. These results suggest the feasibility of a concurrent visualization of QD-based multiple cancer biomarkers using small molecules such as aptamer or peptide ligands.ko_KR
dc.description.sponsorshipThis work
was supported by the Nano Bio Regenomics Project of Korean
Science and Engineering Foundation, Innovation Cluster for
Advanced Medical Imaging Technology, KOSEF MOST (2008-
03767 and M20M04000039-08M0400-03910) and the National
R&D Program for Cancer Control of Ministry of Health&Welfare
(0820320).		ko_KR
dc.language.isoenko_KR
dc.publisherWILEY-V C H VERLAG GMBHko_KR
dc.subjectderby imagingko_KR
dc.subjectnucleolin aptamersko_KR
dc.subjectquantum dotsko_KR
dc.subjectpeptidesko_KR
dc.titleIn vitro Derby Imaging of Cancer Biomarkers Using Quantum Dotsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor고미향-
dc.contributor.AlternativeAuthor김순학-
dc.contributor.AlternativeAuthor강원준-
dc.contributor.AlternativeAuthor이정환-
dc.contributor.AlternativeAuthor강현구-
dc.contributor.AlternativeAuthor문성환-
dc.contributor.AlternativeAuthor황도완-
dc.contributor.AlternativeAuthor고해영-
dc.contributor.AlternativeAuthor이동수-
dc.identifier.doi10.1002/smll.200801580-
dc.citation.journaltitleSMALL-
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dc.description.tc22-
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