S-Space College of Medicine/School of Medicine (의과대학/대학원) Nuclear Medicine (핵의학전공) Journal Papers (저널논문_핵의학전공)
A new PET probe, (18)F-tetrafluoroborate, for the sodium/iodide symporter: possible impacts on nuclear medicine
Cited 10 time in Web of Science Cited 10 time in Scopus
- Issue Date
- EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING; Vol.37 11; 2105-2107
- As early as 1915, it was found that iodide is required in the
thyroid gland for the production of thyroid hormones. Since
then, radioiodines have been used as tracers in thyroid
function tests and as agents for the treatment of hyperthyroidism
and benign thyroid diseases. Furthermore, knowledge
of the importance of the role played by iodine
transport in thyroid cancer cells provides the rationale for
the use of radioiodines to diagnose and treat thyroid cancer
(1, 2). In fact, the clinical utilization of radioiodines led to
the birth of nuclear medicine.
Today, it is known that the iodide pump is a sodium/iodide
symporter (NIS), an intrinsic membrane protein of the thyroid
gland follicular cells (3, 4), and that the NIS-catalysed
accumulation of iodide in cells from the interstitium is
achieved against its transmembrane electrochemical gradient,
which is maintained by sodium-potassium adenosine triphosphatase.
The identification of the human NIS (hNIS)
gene created many new diagnostic and therapeutic opportunities,
and in particular, researchers are currently investigating
the use of hNIS as a reporter gene for gene therapy and
molecular and genomic imaging (5).
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