Browse

Tumor imaging with (68)Ga-positron emission tomography: synthesis and characterization of macrocycle-amino acid derivatives

Cited 0 time in Web of Science Cited 0 time in Scopus
Authors
Shetty, Dinesh; Jeong, Jae Min; Ju, Chang Hwan; Lee, Yun-Sang; Chung, June-Key; Lee, Myung Chul; Lee, Doug Soo
Issue Date
2010-08
Publisher
ELSEVIER SCIENCE INC
Citation
NUCLEAR MEDICINE AND BIOLOGY; Vol.37 6; 688-689
Abstract
68Ga positron emission tomography (PET) imaging in clinical oncology is a
noted development due to cyclotron independent availability. Labeled
amino acid derivatives have been proved useful in imaging many kinds of
tumors. We synthesized 3-aminoalanine, 4-aminohomoalanine and lysine
derivatives of macrocyclic chelating agents by conjugating amino acids to
mono carboxylic group of NOTA and DOTA using either EDC or DCC.
Pure compounds were labeled with 68Ga (labeling efficiency N95%, Specific
Activity ~ 1.94-9.21 GBq/μmol). The preliminary evaluation was studied in
Hep3B and CT-26 cancer cells, which showed high uptake of these
derivatives. Highest in vivo tumor uptake was showed by 68Ga-NOTAaminohomoalanine
(2.40±0.85% ID/g) at 30 min. PET images in mice bearing CT-26 xenografts showed high tumor uptake for 68Ga-NOTAaminohomoalanine
(standard uptake value ratio=12.3±0.05), followed by
68Ga-DOTA-aminoalanine (5.9±0.4). The co-ordination chemistry of
NOTA-mono amide compound was studied by multinuclear nuclear
magnetic resonance analysis. These studies showed the feasibility of using
68Ga amino acid PET for tumor diagnosis.
ISSN
0969-8051
Language
English
URI
https://hdl.handle.net/10371/78326
DOI
https://doi.org/10.1016/j.nucmedbio.2010.04.050
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse