S-Space College of Medicine/School of Medicine (의과대학/대학원) Nuclear Medicine (핵의학전공) Journal Papers (저널논문_핵의학전공)
A pH-dependant structural study on Ga3+complexes with monoamide derivatives of 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) for PET applications
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- Issue Date
- ELSEVIER SCIENCE INC
- NUCLEAR MEDICINE AND BIOLOGY; Vol.37 6; 688-688
- All reported 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) derivatives
for 68Ga labeling include a branched linker or an extra acetic acid,
which require time-consuming multi-step syntheses. We synthesized two
monoamide derivatives of NOTA conjugated with methylamine or
benzylamine to see the possibility of stable Ga3+ complex formation.
Ga3+ complexes were synthesized at different chelating pH values (3 and 5)
and characterized by single crystal X-ray diffraction and multinuclear nuclear magnetic resonance (NMR) spectroscopy. Crystals were obtained by
slow evaporation of ethanol and water solution. X-ray crystal analysis showed
the metal coordination to either nitrogen or oxygen atom of the amide bond at
different chelation pH to form stable hexadentate complex. At pH 5, both
ligands showed coordination to amide nitrogen. However, at pH 3, oxygen
atom of amide bond was coordinated with gallium in case of benzylamine
derivative, while methylamine derivative always showed nitrogen coordination.
In solution chemistry, 71Ga NMR at range of pH showed possibility
of two different coordination. Variable temperature 1H NMR spectroscopy
showed the rigidity of these complexes. This finding could open up a wide
range of applications for NOTA type bifunctional chelating agents by
eliminating the multi-step synthesis required to introduce extra linkers.
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