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The Effect of Curculigoside on the Expression of Matrix Metalloproteinase-1 in Cultured Human Skin Fibroblasts

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dc.contributor.authorLee, Song-Yi-
dc.contributor.authorKim, Mi-Ran-
dc.contributor.authorChoi, Hong Seok-
dc.contributor.authorMoon, Hyung-In-
dc.contributor.authorLee, Dong Gun-
dc.contributor.authorWoo, Eun-Rhan-
dc.contributor.authorChung, Jin Ho-
dc.date.accessioned2012-07-04T00:24:40Z-
dc.date.available2012-07-04T00:24:40Z-
dc.date.issued2009-10-
dc.identifier.citationARCHIVES OF PHARMACAL RESEARCH; Vol.32 10; 1433-1439ko_KR
dc.identifier.issn0253-6269-
dc.identifier.urihttps://hdl.handle.net/10371/78336-
dc.description.abstractThe dried rhizomes of Curculigo orchioides G. yielded two phenolic glycosides, curculigoside (1), orcinol-beta-D-glucoside (4), and two cycloartane saponins, curculigosaponin G (2), curculigosaponin I (3). The structures were determined using spectroscopic methods. Among these isolates, compound 1 exhibited potent inhibitory activity against matrix metalloproteinase-1 in cultured human skin fibroblasts. In addition, it increased the level of Bcl-2 protein expression and decreased the level of Bax protein expression. Compound 4 was isolated from this plant for the first time.ko_KR
dc.description.sponsorshipThis study was supported by a grant from Chosun
University 2009.		ko_KR
dc.language.isoenko_KR
dc.publisherPHARMACEUTICAL SOC KOREAko_KR
dc.subjectCurculigo orchioides G.ko_KR
dc.subjectMatrix metalloproteinase-1ko_KR
dc.subjectType-1 procollagenko_KR
dc.subjectCycloartane saponinko_KR
dc.subjectAmaryllidaceaeko_KR
dc.subjectPhenolic glycosideko_KR
dc.subjectCurculigosideko_KR
dc.titleThe Effect of Curculigoside on the Expression of Matrix Metalloproteinase-1 in Cultured Human Skin Fibroblastsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이송이-
dc.contributor.AlternativeAuthor김미란-
dc.contributor.AlternativeAuthor최홍석-
dc.contributor.AlternativeAuthor문형인-
dc.contributor.AlternativeAuthor정진호-
dc.contributor.AlternativeAuthor이동건-
dc.contributor.AlternativeAuthor우은란-
dc.identifier.doi10.1007/s12272-009-2013-4-
dc.citation.journaltitleARCHIVES OF PHARMACAL RESEARCH-
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dc.description.tc3-
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