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Ultraviolet irradiation induces thrombospondin-1 which attenuates type I procollagen downregulation in human dermal fibroblasts
DC Field | Value | Language |
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dc.contributor.author | Seo, Jo-Eun | - |
dc.contributor.author | Kim, Sangmin | - |
dc.contributor.author | Shin, Mi Hee | - |
dc.contributor.author | Kim, Mi-Sun | - |
dc.contributor.author | Park, Chi-Hyun | - |
dc.contributor.author | Chung, Jin Ho | - |
dc.contributor.author | Eun, Hee Chul | - |
dc.date.accessioned | 2012-07-04T00:38:05Z | - |
dc.date.available | 2012-07-04T00:38:05Z | - |
dc.date.issued | 2010-07 | - |
dc.identifier.citation | JOURNAL OF DERMATOLOGICAL SCIENCE; Vol.59(1); 16-24 | ko_KR |
dc.identifier.issn | 0923-1811 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78340 | - |
dc.description.abstract | Background: Thrombospondin-1 (TSP-1) is a matricellular glycoprotein and recognized as an inhibitor of angiogenesis and an activator of transforming growth factor-beta (TGF-beta). Although TSP-1 expression has been shown to be regulated by various stimuli including UV in some types of cell, more work need to be done to understand the regulation of TSP-1 expression and its functional significances in many other types of cell. Objective: In this study, we investigated the effect of UV on TSP-1 expression in human skin dermis and dermal fibroblasts and the role of TSP-1 on the type I procollagen expression after UV exposure. Methods: Human buttock skin and human dermal fibroblasts were irradiated with UV. The mRNA and the protein levels of TSP-1 or type I procollagen were measured by real-time polymerase chain reaction and Western blotting, respectively. Results: We found that UV irradiation increased TSP-1 expression at the mRNA and protein levels in human skin dermis and dermal fibroblasts. UV-induced TSP-1 expression was greatly suppressed by inhibition of the PI3K, Akt, or mTOR pathways. The inhibition of TSP-1 activity by a blocking peptide or suppression of TSP-1 expression by specific TSP-1 small interfering RNA augmented the UV-induced decrease of type I procollagen expression. Conclusion: Our results suggest that UV-induced TSP-1 plays an important role on alleviating and/or recovering the type I procollagen expression downregulated by UV in human dermal fibroblasts. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ELSEVIER IRELAND LTD | ko_KR |
dc.subject | UV irradiation | ko_KR |
dc.subject | Fibroblasts | ko_KR |
dc.subject | TSP-1 | ko_KR |
dc.subject | Procollagen | ko_KR |
dc.subject | Dermis | ko_KR |
dc.title | Ultraviolet irradiation induces thrombospondin-1 which attenuates type I procollagen downregulation in human dermal fibroblasts | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 서조은 | - |
dc.contributor.AlternativeAuthor | 김상민 | - |
dc.contributor.AlternativeAuthor | 신미희 | - |
dc.contributor.AlternativeAuthor | 김미선 | - |
dc.contributor.AlternativeAuthor | 은희철 | - |
dc.contributor.AlternativeAuthor | 박치현 | - |
dc.contributor.AlternativeAuthor | 정진호 | - |
dc.identifier.doi | 10.1016/j.jdermsci.2010.04.010 | - |
dc.citation.journaltitle | JOURNAL OF DERMATOLOGICAL SCIENCE | - |
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