Vitamin D receptor depletion by Wnt/beta-catenin signaling caused alopecia areata in human Immunobiology, Alopecia Areata

Abstract

Vitamin D receptor (VDR) is expressed in the epidermal component of hair follicle and dermal papilla cell and the lack of VDR results alopecia. In this study, we investigated the VDR expression in the human normal follicle and the alopecia areata (AA). First, we demonstrated human tissue was taken for immunohistochemical staing for b-catenin, Wnt3a, Wnt5a, Wnt10b, proliferating cell nuclear antigen (PCNA), involucrin and filaggrin.