Successful treatment of plasma cell cheilitis with topical calcineurin inhibitors

Abstract

Plasma cell cheilitis (PCC) is a rare, idiopathic, benign, inflammatory disorder characterized by a dense accumulation of plasma cells in the upper dermis. The authors describe two cases of PCC recalcitrant to topical steroids that resolved after topical tacrolimus ointment administration, and one case of PCC with steroid-induced labial atrophy that also responded well to topical pimecrolimus and tacrolimus.