S-Space College of Medicine/School of Medicine (의과대학/대학원) Dermatology (피부과학전공) Journal Papers (저널논문_피부과학전공)
Hair growth promoting effects of adipose tissue-derived stem cells
- Won, Chong Hyun; Yoo, Hyeon Gyeong; Kwon, Oh Sang; Sung, Mi Young; Chung, Jin Ho; Sung, Jong-Hyuk; Kim, Kyu Han; Kim, Won Serk; Park, Byung Soon; Kang, Yong Jung
- Issue Date
- ELSEVIER IRELAND LTD
- JOURNAL OF DERMATOLOGICAL SCIENCE; Vol.57 2; 134-137
- Adipose tissue-derived stem cells (ADSCs) can display multilineage
plasticity and share similar characteristics with bone
marrow-derived mesenchymal stem cells . Moreover, ADSCs
have various cytokine-secreting properties and beneficial paracrine
effects on surrounding cells or tissues . Recently, paracrine
function is considered one of the most important therapeutic
benefits of therapy using mesenchymal stem cells [3,4].
Regarding hair biology, several reports have demonstrated that
growth factors from the surroundings stimulate hair growth in ex
vivo and animal models [5,6].We have identified secretory factors
derived from ADSCs by ELISA and proteomics previously, including
IGF binding protein precursors, PDGF, KGF, HGF, VEGF, and
fibronectin [7,8]. These factors are well-documented to be related
to hair growth stimulation . To determine whether these
paracrine effects of ADSCs can promote hair growth, we
investigated the effects of ADSCs on hair.
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