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Hair growth promoting effects of adipose tissue-derived stem cells

Cited 52 time in Web of Science Cited 53 time in Scopus
Authors
Won, Chong Hyun; Yoo, Hyeon Gyeong; Kwon, Oh Sang; Sung, Mi Young; Chung, Jin Ho; Sung, Jong-Hyuk; Kim, Kyu Han; Kim, Won Serk; Park, Byung Soon; Kang, Yong Jung
Issue Date
2010-02
Publisher
ELSEVIER IRELAND LTD
Citation
JOURNAL OF DERMATOLOGICAL SCIENCE; Vol.57 2; 134-137
Abstract
Adipose tissue-derived stem cells (ADSCs) can display multilineage
plasticity and share similar characteristics with bone
marrow-derived mesenchymal stem cells [1]. Moreover, ADSCs
have various cytokine-secreting properties and beneficial paracrine
effects on surrounding cells or tissues [2]. Recently, paracrine
function is considered one of the most important therapeutic
benefits of therapy using mesenchymal stem cells [3,4].
Regarding hair biology, several reports have demonstrated that
growth factors from the surroundings stimulate hair growth in ex
vivo and animal models [5,6].We have identified secretory factors
derived from ADSCs by ELISA and proteomics previously, including
IGF binding protein precursors, PDGF, KGF, HGF, VEGF, and
fibronectin [7,8]. These factors are well-documented to be related
to hair growth stimulation [6]. To determine whether these
paracrine effects of ADSCs can promote hair growth, we
investigated the effects of ADSCs on hair.
ISSN
0923-1811
Language
English
URI
http://hdl.handle.net/10371/78362
DOI
https://doi.org/10.1016/j.jdermsci.2009.10.013
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College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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