S-Space College of Medicine/School of Medicine (의과대학/대학원) Dermatology (피부과학전공) Journal Papers (저널논문_피부과학전공)
Clinical and histopathologic review on 28 cases of nodular fasciitis
- Choi, Mira; Won, Chong Hyun; Kwon, In Ho; Cho, Soyun
- Issue Date
- JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY; Vol.62 3; AB52-AB52
- Background: Nodular fasciitis presents a solitary, slightly painful, rapidly growing
nodule. It is associated with a reactive, proliferative process of unknown cellular
origin and can be misdiagnosed as a sarcoma.
Objective: The study was designed to investigate the process and cellular origin of
Methods: The clinical and histopathologic findings in 28 cases of nodular fasciitis
were reviewed. Additional various histochemical and immunohistochemical stainings
Results: (1) The mean age of onset was 29.8 years. A majority of the patients with
nodular fasciitis have the duration of symptom less than 6 months. The upper
extremity and face were most frequently involved. Most of the lesions had the
diameter of less than 2 cm. Total excisions were performed in 23 lesions, of which
three lesions recurred thereafter. (2) Histopathologically, the subcutaneous plane
was most frequently involved. The nodule consisted of numerous large, pleomorphic
fibroblasts growing haphazardly in a vascular stroma containing varying
amounts of mucoid ground substance, which could be confirmed by histochemical
stains. (3) In the immunohistochemical stain, most lesions have positive finding for
smooth muscle actin (SMA), vimentin, and negative finding for CD34, except a few
cases. The stains for desmin and S-100 were negative in all cases.
Conclusions: It is suggested that nodular fasciitis could be associated with a reactive
proliferation of myofibroblasts rather than a sarcomatous process.
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