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ALTERED FUNCTIONAL CONNECTIVITY IN SUBJECTS WITH ULTRA-HIGH RISK FOR PSYCHOSIS USING RESTING STATE FMRI
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Jun Soo | - |
dc.contributor.author | Shim, Geumsook | - |
dc.contributor.author | Oh, Jungsu S. | - |
dc.contributor.author | Jung, Wi Hoon | - |
dc.contributor.author | Choi, Chi-Hoon | - |
dc.contributor.author | Park, Hye-Yoon | - |
dc.contributor.author | Jung, Myung Hun | - |
dc.contributor.author | Choi, Jung-Seok | - |
dc.contributor.author | Kim, Euitae | - |
dc.contributor.author | Jang, Joon Hwan | - |
dc.date.accessioned | 2012-07-04T04:33:41Z | - |
dc.date.available | 2012-07-04T04:33:41Z | - |
dc.date.issued | 2010-04 | - |
dc.identifier.citation | SCHIZOPHRENIA RESEARCH; Vol.117 2-3; 348-349 | ko_KR |
dc.identifier.issn | 0920-9964 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78393 | - |
dc.description.abstract | Background: Several functional magnetic resonance imaging (fMRI)
studies of schizophrenia have revealed the default mode network (DMN) and task-related network (TRN) abnormalities during resting-state. Midline default network areas, including the medial prefrontal cortex and posterior cingulate cortex, are implicated in self-referential and social cognitive tasks, and individuals at ultrahigh risk (UHR) for psychosis were recently reported to have selfdisturbances and deficits in social cognition and functioning. Thus, the DMN has its potential to reveal the neural substrates of selfreferential and social cognitive information processing in UHR subjects. In this study, we investigated resting-state DMN and TRN functional connectivity in UHR subjects and healthy controls. Methods: Twenty UHR subjects and 20 matched healthy controls underwent fMRI while resting quietly. We selected bilateral posterior cingulate cortex (Brodmann area 23) as a seed region and reconstructed the intrinsic organization in the UHR subjects and healthy controls on the basis of fMRI time series correlation (also known as functional connectivity). Between-group comparison of the DMN and TRN was restricted to regions belonging to the intrinsic networks of control group. Additionally, we also conducted between-group region of interest (ROI)-based connectivity analyses on areas in which UHR subjects showed altered connectivities, within a priori selected anatomical ROIs. Results: Default mode and task-related areas were observed in regions previously associated with the DMN and TRN for both groups. Default mode areas included the posterior/anterior cingulate, medial prefrontal and lateral parietal cortices, and inferior/ superior temporal gyri, whereas task-related areas included the dorsolateral prefrontal and middle temporal cortex, supplementary motor area, and frontal eye field. Compared to healthy controls, UHR subjects exhibited hyperconnectivity within the default network regions and reduced anti-correlations between the posterior cingulate cortex and task-related areas. Between-group ROI analysis also confirmed these findings. Discussion: Our findings suggest that abnormal hyperconnectivity of the default areas in UHR subjects might be related with clinical features of UHR subjects like disturbance of self-perception and heightened social anxiety. Neurodevelopmental and anatomical alterations of cortical midline structure might underlie altered intrinsic networks in UHR subjects. We also speculate that reduced anti-correlation between two networks might be related with impaired neurocognitive function in UHR subjects, which might be mediated by weaker task-induced deactivation of the DMN. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ELSEVIER SCIENCE BV | ko_KR |
dc.title | ALTERED FUNCTIONAL CONNECTIVITY IN SUBJECTS WITH ULTRA-HIGH RISK FOR PSYCHOSIS USING RESTING STATE FMRI | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 권준수 | - |
dc.contributor.AlternativeAuthor | 심금숙 | - |
dc.contributor.AlternativeAuthor | 오정수 | - |
dc.contributor.AlternativeAuthor | 정이훈 | - |
dc.contributor.AlternativeAuthor | 장준환 | - |
dc.contributor.AlternativeAuthor | 최치훈 | - |
dc.contributor.AlternativeAuthor | 김의태 | - |
dc.contributor.AlternativeAuthor | 박혜윤 | - |
dc.contributor.AlternativeAuthor | 최정석 | - |
dc.contributor.AlternativeAuthor | 정명훈 | - |
dc.identifier.doi | 10.1016/j.schres.2010.02.610 | - |
dc.citation.journaltitle | SCHIZOPHRENIA RESEARCH | - |
dc.description.tc | 0 | - |
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