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Association between CLOCK 3111T/C and preferred circadian phase in Korean patients with bipolar disorder

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dc.contributor.authorLee, Kyu Young-
dc.contributor.authorSong, Joo Yun-
dc.contributor.authorKim, Se Hyun-
dc.contributor.authorKim, Seong Chan-
dc.contributor.authorAhn, Yong Min-
dc.contributor.authorKim, Yong Sik-
dc.contributor.authorJoo, Eun-Jeong-
dc.date.accessioned2012-07-04T05:57:49Z-
dc.date.available2012-07-04T05:57:49Z-
dc.date.issued2010-10-01-
dc.identifier.citationPROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY; Vol.34 7; 1196-1201ko_KR
dc.identifier.issn0278-5846-
dc.identifier.urihttps://hdl.handle.net/10371/78420-
dc.description.abstractGenes associated with circadian rhythms have been suggested to play an important role in the pathophysiology of bipolar disorder A single nucleotide polymorphism (SNP) in the 3`-flanking region of CLOCK (3111T/C, rs1801260) has been reported to be associated with sleep disturbances and an increased recurrence rate in patients with bipolar disorder. We examined the association of CLOCK 3111T/C with bipolar disorder in 260 patients and 350 controls in a Korean population CLOCK 3111T/C showed significant allelic and genotypic associations with bipolar disorder (P=0.012, P=0 033, respectively) Morningness/eveningness (M/E) was evaluated using the Composite Scale of Morningness (CSM) in 108 patients with bipolar disorder In the subgroup analysis of the highest and lowest 25th percentile of M/E scores, significantly more C allele carriers were found among extreme evening types than among extreme morning types (P= 0.041) After correcting for age. C allele carriers had lower M/E scores than those carrying the T/T genotype, but the association was not statistically significant We also analyzed the association between age at onset (AAO) and CLOCK 3111T/C in the bipolar disorder group, and no association was found Despite the relatively small sample sizes, these results support a possible role of the CLOCK 3111T/C SNP in bipolar disorder. Further studies with larger samples and more polymorphisms are necessary (C) 2010 Elsevier Inc All rights reservedko_KR
dc.description.sponsorshipThis research was supported by a grant (A080534) from the Korea
Health 21 R&D project, Ministry for Health, Welfare and Family
Affairs, Republic of Korea.
ko_KR
dc.language.isoenko_KR
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDko_KR
dc.subjectAge at onsetko_KR
dc.subjectMorningness/eveningnessko_KR
dc.subjectBipolar disorderko_KR
dc.subjectCLOCKko_KR
dc.subjectKoreanko_KR
dc.titleAssociation between CLOCK 3111T/C and preferred circadian phase in Korean patients with bipolar disorderko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이규영-
dc.contributor.AlternativeAuthor송주윤-
dc.contributor.AlternativeAuthor김세현-
dc.contributor.AlternativeAuthor김성찬-
dc.contributor.AlternativeAuthor주은정-
dc.contributor.AlternativeAuthor안용민-
dc.contributor.AlternativeAuthor김용식-
dc.identifier.doi10.1016/j.pnpbp.2010.06.010-
dc.citation.journaltitlePROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY-
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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