Publications
Detailed Information
Reduced Population and Impaired Osteogenic Potential of Bone Marrow-Derived Mesenchymal Stem Cells in Streptozocin-Induced Diabetic Rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Bong Cheol | - |
dc.contributor.author | Yoo, Jeong Joon | - |
dc.contributor.author | Nam, Kwang Woo | - |
dc.contributor.author | Kim, Hee Joong | - |
dc.date.accessioned | 2012-07-04T06:03:53Z | - |
dc.date.available | 2012-07-04T06:03:53Z | - |
dc.date.issued | 2009-06 | - |
dc.identifier.citation | TISSUE ENGINEERING AND REGENERATIVE MEDICINE; Vol.6, 04월 11일; 453-460 | ko_KR |
dc.identifier.issn | 1738-2696 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78423 | - |
dc.description.abstract | Cell therapy using mesenchymal stein cells(MSCs) from different donors is considered a promising therapeutic method for a variety of diseases. However, the possibility of donor-specific variations in the biological characteristics of MSCs requires further elucidation to ensure their optimal clinical usages. The authors examined the isolation yields and osteogenic potentials of bone marrow derived MSCs from diabetic rats to investigate the notion that diabetes adversely affects the functions of MSCs. Sprague-Dawley rats with and without streptozocin induced diabetes were followed for 3 weeks and allocated to a tightly controlled group(TDR), a poorly controlled group(PDR), or to a non-streptozocin-treated normal control group(CR). Isolation yields and the osteogenic differentiation potentials of MSCs from bone marrow were then assayed. Numbers of colony forming unit-fibroblasts(CFU-Fs) and alkaline phosphatase(ALP) positive CFU-Fs were significantly lower in the PDR group than in the other groups. During osteogenic differentiation, cell proliferation rates and ALP activities were not significantly different in the three groups, whereas calcium contents, numbers of bone nodules, and osteocalcin mRNA levels were significantly lower in the PDR group. Our study demonstrates that MSCs isolation yields and osteogenic potentials are lower in diabetic rats, and suggests that the presence of diabetes be considered when selecting MSC donors. | - |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC | ko_KR |
dc.subject | Diabetes | - |
dc.subject | mesenchymal stem cell | - |
dc.subject | osteogenic differentiation | - |
dc.subject | isolation yield | - |
dc.title | Reduced Population and Impaired Osteogenic Potential of Bone Marrow-Derived Mesenchymal Stem Cells in Streptozocin-Induced Diabetic Rats | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 권봉철 | - |
dc.contributor.AlternativeAuthor | 유정준 | - |
dc.contributor.AlternativeAuthor | 남광우 | - |
dc.contributor.AlternativeAuthor | 김희중 | - |
dc.citation.journaltitle | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | - |
dc.description.citedreference | Liu ZJ, 2008, ANTIOXID REDOX SIGN, V10, P1869, DOI 10.1089/ars.2008.2121 | - |
dc.description.citedreference | Planka L, 2008, BMC BIOTECHNOL, V8, DOI 10.1186/1472-6750-8-70 | - |
dc.description.citedreference | Caplan AI, 2008, CELL STEM CELL, V3, P229, DOI 10.1016/j.stem.2008.08.008 | - |
dc.description.citedreference | Uccelli A, 2008, NAT REV IMMUNOL, V8, P726, DOI 10.1038/nri2395 | - |
dc.description.citedreference | Chan WH, 2008, J CELL BIOCHEM, V103, P1144, DOI 10.1002/jcb.21489 | - |
dc.description.citedreference | Dong QY, 2008, CLIN INVEST MED, V31, pE328 | - |
dc.description.citedreference | Kotobuki N, 2008, CELL TRANSPLANT, V17, P705 | - |
dc.description.citedreference | BAHK JY, 2008, INT J STEM CELLS, V1, P91 | - |
dc.description.citedreference | YOO JJ, 2008, INT ORTHOP 0219 | - |
dc.description.citedreference | KURTZ A, 2008, INT J STEM CELLS, V1, P1 | - |
dc.description.citedreference | Khang G, 2007, TISSUE ENG REGEN MED, V4, P441 | - |
dc.description.citedreference | Ball LM, 2007, BLOOD, V110, P2764, DOI 10.1182/blood-2007-04-087056 | - |
dc.description.citedreference | Gao Q, 2007, INT J DEV NEUROSCI, V25, P349, DOI 10.1016/j.ijdevneu.2007.08.002 | - |
dc.description.citedreference | Augello A, 2007, ARTHRITIS RHEUM, V56, P1175, DOI 10.1002/art.22511 | - |
dc.description.citedreference | Scharstuhl A, 2007, STEM CELLS, V25, P3244, DOI 10.1634/stemcells.2007.0300 | - |
dc.description.citedreference | Friedman MS, 2006, J CELL BIOCHEM, V98, P538, DOI 10.1002/jcb.20719 | - |
dc.description.citedreference | Stolzing A, 2006, REJUV RES, V9, P31 | - |
dc.description.citedreference | DASILVAMEIRELLE.L, 2006, J CELL SCI, V119, P2204 | - |
dc.description.citedreference | Zappia E, 2005, BLOOD, V106, P1755, DOI 10.1182/blood-2005-04-1496 | - |
dc.description.citedreference | Kume S, 2005, J BONE MINER RES, V20, P1647, DOI 10.1359/JBMR.050514 | - |
dc.description.citedreference | Banerjee M, 2005, BIOCHEM BIOPH RES CO, V328, P318, DOI 10.1016/j.bbrc.2004.12.176 | - |
dc.description.citedreference | Suh KT, 2005, CLIN ORTHOP RELAT R, P220, DOI 10.1097/01.blo.0000150568.16133.3c | - |
dc.description.citedreference | Lecomte M, 2004, BBA-MOL BASIS DIS, V1689, P202, DOI 10.1016/j.bbadis.2004.03.010 | - |
dc.description.citedreference | Sekido H, 2004, BIOCHEM BIOPH RES CO, V320, P241, DOI 10.1016/j.bbrc.2004.05.159 | - |
dc.description.citedreference | LE BK, 2004, LANCET, V363, P1439 | - |
dc.description.citedreference | BARTUS CL, 2004, CURR DIABETES REP, V4, P413 | - |
dc.description.citedreference | Leskela HV, 2003, BIOCHEM BIOPH RES CO, V311, P1008, DOI 10.1016/j.bbrc.2003.10.095 | - |
dc.description.citedreference | Santana RB, 2003, DIABETES, V52, P1502 | - |
dc.description.citedreference | BANERJEE M, 2003, J PANCREAS, V4, P137 | - |
dc.description.citedreference | Lu HF, 2003, ENDOCRINOLOGY, V144, P346, DOI 10.1210/en.2002-220072 | - |
dc.description.citedreference | Murphy JM, 2002, ARTHRITIS RHEUM, V46, P704, DOI 10.1002/art.10118 | - |
dc.description.citedreference | Guz Y, 2001, ENDOCRINOLOGY, V142, P4956 | - |
dc.description.citedreference | Caplan AI, 2001, TRENDS MOL MED, V7, P259 | - |
dc.description.citedreference | Stenderup K, 2001, J BONE MINER RES, V16, P1120 | - |
dc.description.citedreference | Muschler GF, 2001, J ORTHOPAED RES, V19, P117 | - |
dc.description.citedreference | Deans RJ, 2000, EXP HEMATOL, V28, P875 | - |
dc.description.citedreference | GUGLIUCCI A, 2000, J AM OSTEOPATH ASSOC, V100, P621 | - |
dc.description.citedreference | Phinney DG, 1999, J CELL BIOCHEM, V75, P424 | - |
dc.description.citedreference | D`Ippolito G, 1999, J BONE MINER RES, V14, P1115 | - |
dc.description.citedreference | Pittenger MF, 1999, SCIENCE, V284, P143 | - |
dc.description.citedreference | Oreffo ROC, 1998, SCAND J RHEUMATOL, V27, P415 | - |
dc.description.citedreference | Hernigou P, 1997, J BONE JOINT SURG AM, V79A, P1047 | - |
dc.description.citedreference | Lyons TJ, 1997, CURR OPIN LIPIDOL, V8, P174 | - |
dc.description.citedreference | Jaiswal N, 1997, J CELL BIOCHEM, V64, P295 | - |
dc.description.citedreference | Ducy P, 1996, NATURE, V382, P448 | - |
dc.description.citedreference | Bergman RJ, 1996, J BONE MINER RES, V11, P568 | - |
dc.description.citedreference | Aubin JE, 1996, MICROSC RES TECHNIQ, V33, P128 | - |
dc.description.citedreference | QUARTO R, 1995, CALCIFIED TISSUE INT, V56, P123 | - |
dc.description.citedreference | YOUNG HE, 1995, DEV DYNAM, V202, P137 | - |
dc.description.citedreference | TAKAHASHI M, 1993, DIABETOLOGIA, V36, P664 | - |
dc.description.citedreference | BRIGHTON CT, 1992, CLIN ORTHOP RELAT R, P287 | - |
dc.description.citedreference | STRIKER LJ, 1991, LAB INVEST, V64, P446 | - |
dc.description.citedreference | OWEN TA, 1990, J CELL PHYSIOL, V143, P420 | - |
dc.description.citedreference | LODER RT, 1988, CLIN ORTHOP RELAT R, P210 | - |
dc.description.tc | 0 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.