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Changes in heart rate dynamics of patients with schizophrenia treated with risperidone
DC Field | Value | Language |
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dc.contributor.author | Chang, Jae Seung | - |
dc.contributor.author | Yoo, Cheol Sung | - |
dc.contributor.author | Yi, Sang Hoon | - |
dc.contributor.author | Hong, Kye Hyun | - |
dc.contributor.author | Oh, Hong Seok | - |
dc.contributor.author | Kim, Yong Sik | - |
dc.contributor.author | Ahn, Yong Min | - |
dc.contributor.author | Jung, Dong Chung | - |
dc.contributor.author | Lee, Yu-Sang | - |
dc.date.accessioned | 2012-07-04T06:34:39Z | - |
dc.date.available | 2012-07-04T06:34:39Z | - |
dc.date.issued | 2010-08-16 | - |
dc.identifier.citation | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY; Vol.34 6; 924-929 | ko_KR |
dc.identifier.issn | 0278-5846 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78437 | - |
dc.description.abstract | Neurocardiac dysregulation has been reported in schizophrenia. Indices of heart rate variability (HRV) are useful in assessing the status of cardiac autonomic regulation. We explored within-subject changes in HRV indices in acutely ill patients with schizophrenia treated with risperidone. Sixteen medication-naive or medication-free patients with DSM-IV schizophrenia completed electrocardiogram (ECG) assessments at baseline and after six weeks of treatment with risperidone. Indices of HRV were extracted from 5-min resting ECG recordings and compared to those obtained from control subjects matched for age and gender. Psychiatric and drug-induced extrapyramidal symptoms were assessed by the Positive and Negative Syndrome Scale (PANSS) and the Drug-Induced Extrapyramidal Symptoms Scale (1DIEPSS). In comparison with matched controls, patients with acute schizophrenia showed lower values of time-domain measures, lower high-frequency power (HF) and a higher ratio of low to high frequency (LF/HF). In the within-subject analyses, a significant decrease in LF/HF was associated with risperidone treatment. In addition, LF/HF, which initially co-clustered with clinical variables, congregated with other HRV measures after the six-week risperidone treatment. These results indicate that, in the therapeutic process, risperidone treatment may exert a beneficial influence on the sympathovagal imbalance in acute schizophrenia. (C) 2010 Elsevier Inc. All rights reserved. | ko_KR |
dc.description.sponsorship | This study was supported in part by grant A090828 of the Korea
Healthcare Technology R & D project, Ministry of Health, Welfare & Family Affairs, Republic of Korea, and in part by grant 11-2008-017 from the Seoul National University Bundang Hospital Research Fund. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | ko_KR |
dc.subject | Heart rate variability | ko_KR |
dc.subject | Risperidone | ko_KR |
dc.subject | Sympathovagal balance | ko_KR |
dc.subject | Schizophrenia | ko_KR |
dc.title | Changes in heart rate dynamics of patients with schizophrenia treated with risperidone | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 장재승 | - |
dc.contributor.AlternativeAuthor | 유철성 | - |
dc.contributor.AlternativeAuthor | 이상훈 | - |
dc.contributor.AlternativeAuthor | 홍계현 | - |
dc.contributor.AlternativeAuthor | 이유상 | - |
dc.contributor.AlternativeAuthor | 오홍석 | - |
dc.contributor.AlternativeAuthor | 정동청 | - |
dc.contributor.AlternativeAuthor | 김용식 | - |
dc.contributor.AlternativeAuthor | 안용민 | - |
dc.identifier.doi | 10.1016/j.pnpbp.2010.04.017 | - |
dc.citation.journaltitle | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | - |
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