Impact of genetic polymorphism on resting state functional connectivity in healthy subjects

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Byun, M. S.; Jung, W. H.; Jang, J. H.; Kang, D. H.; Choi, C. H.; Kwon, J. S.; Kwon, S. J.

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Brain-derived neurotrophic factor (BDNF) val66met polymorphism
and catechol-O-methyltransferase (COMT) val158met
polymorphism have been reported to affect neuropsychological
function and brain structure. Functional imaging studies also
revealed that these genetic polymorphisms have linked with activations
of several brain regions during the task but there are only
few studies about the impact of these genetic variations on the
resting state functional connectivity. In this study, we hypothesized
that there might be a difference in patterns of resting functional
connectivity between BDNF and COMT genetic polymorphisms.
To test these hypotheses, we used functional MRI (fMRI) to
examine brain activity in a group of 23 healthy right-handed
subjects (15 male/8 female; age: 24.13±3.67 years old). The
Structured Clinical Interview for DSM-IV Non-patient Version
was used to assess all participants to identify past and current
psychiatric illnesses. The Korean version of the Wechsler Adult
Intelligence Scale (K-WAIS) were also administered to all subjects
(mean IQ: 112.96±9.99, mean years of education: 14.43 ±1.38
years). Whole blood was collected for genotyping and BDNF
val66met and COMT val158met polymorphisms were detected
by TaqMan allelic discrimination assays on ABI Prism 7500 Sequence
Detection System. Functional imaging data were acquired
using a 1.5-Tesla Avanto scanner while subjects kept their eyes
closed during the scan. The posterior cingulate cortex (PCC) was
selected as the seed region for the default mode network map and
Statistical Parametric Mapping (SPM5) and REST package (REST
version 1.3) were used to examine the functional connectivity
of the PCC for each subject. According to the genotype, we
divided subjects into two groups for each polymorphism: valallele
homozygotes (n = 11)/met-allele carriers (n = 12) of BDNF
val66met polymorphism and val-allele homozygotes (n = 8)/metallele
carriers (n = 15) of COMT val158met polymorphism. A onesample
t-test was performed for within-group analysis and a twosample
t-test was used to examine the difference in the degree of
functional connectivity between two groups.
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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