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Clinical and immunologic effects of sublingual immunotherapy on patients with allergic rhinitis to house-dust mites: 1-Year follow-up results

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dc.contributor.authorKim, Seung-Tae-
dc.contributor.authorHan, Doo Hee-
dc.contributor.authorMoon, Il Joon-
dc.contributor.authorLee, Chul Hee-
dc.contributor.authorRhee, Chae-Seo-
dc.contributor.authorMin, Yang-Gi-
dc.identifier.citationAMERICAN JOURNAL OF RHINOLOGY & ALLERGY; Vol.24 4; 271-275ko_KR
dc.description.abstractBackground: There have been no data on sublingual immunotherapy (SLIT) in Asian patients with allergic rhinitis (AR) sensitized to house-dust mites (HDMs). This study aimed to investigate the efficacy and immunologic change after 12 months of SLIT in Korean patients. Methods: Fifty-eight patients, who had AR caused by Dermatophagoides pteronyssinus and Dermatophagoides farinae and who completed 12 months of SLIT were included. Symptom scores were evaluated before and after 12 months of SLIT, and medication scores were assessed throughout the study. Peripheral blood eosinophil counts, eosinophil cationic protein (ECP), total IgE, and specific IgE were also evaluated. Results: All of the symptoms of AR were significantly improved with reduced medication scores. In addition, there were significant decrements in peripheral blood eosinophil counts and ECP (p = 0.025 and p = 0.048, respectively). Specific IgE for D. farinae slightly increased (p = 0.019), whereas specific IgE for D. pteronyssinus and total IgE did not change significantly. Thirty-six (62%) of 58 patients were in the effective response group. Although not statistically significant, findings in the study showed that the effective response group had a tendency to have lug-her ECP levels before SLIT than the ineffective response group (p = 0.056). Conclusion: SLIT improved the symptoms and medication scores in Korean patients with AR from HDM. Laboratory parameters including eosinophil counts, ECP, and specific IgE for D. farinae seemed to be modified after 1-year SLIT. A high ECP level may be a useful parameter to predict the effectiveness of SLIT and select the patient for the treatment. (Am J Rhinol Allergy 24, 271-275, 2010; doi: 10.2500/ajra.2010.24.3501)ko_KR
dc.subjectAllergic rhinitisko_KR
dc.subjecthouse dust mitesko_KR
dc.subjectsublingual immunotherapyko_KR
dc.subjectpatient selectionko_KR
dc.subjecteosinophil cationic proteinko_KR
dc.subjectDermatophagoides pteronyssinusko_KR
dc.subjectDermatophagoides farinaeko_KR
dc.titleClinical and immunologic effects of sublingual immunotherapy on patients with allergic rhinitis to house-dust mites: 1-Year follow-up resultsko_KR
dc.description.citedreferenceCompalati E, 2009, ALLERGY, V64, P1570, DOI 10.1111/j.1398-9995.2009.02129.x-
dc.description.citedreferenceChang H, 2009, CLIN EXP OTORHINOLAR, V2, P136, DOI 10.3342/ceo.2009.2.3.136-
dc.description.citedreferencede Groot H, 2009, ALLERGY, V64, P963, DOI 10.1111/j.1398-9995.2009.01998.x-
dc.description.citedreferenceDi Lorenzo G, 2009, J ALLERGY CLIN IMMUN, V123, P1103, DOI 10.1016/j.jaci.2009.02.012-
dc.description.citedreferenceFrew AJ, 2008, NEW ENGL J MED, V358, P2259-
dc.description.citedreferenceSaporta D, 2008, AM J RHINOL, V22, P253, DOI 10.2500/ajr.2008.22.3131-
dc.description.citedreferenceBlazowski L, 2008, ALLERGY, V63, P374, DOI 10.1111/j.1398-9995.2007.01563.x-
dc.description.citedreferenceLarenas-Linnemann DE, 2008, ALLERGY ASTHMA PROC, V29, P130, DOI 10.2500/aap.2008.29.3093-
dc.description.citedreferenceBOUSQUET J, 2008, ALLERGY S, V86, P8-
dc.description.citedreferenceTahamiler R, 2007, LARYNGOSCOPE, V117, P965, DOI 10.1097/MLG.0b013e31804f8141-
dc.description.citedreferenceEifan AO, 2007, ALLERGY, V62, P567, DOI 10.1111/j.1398-9995.2006.01301.x-
dc.description.citedreferenceCanonica GW, 2007, ALLERGY, V62, P317, DOI 10.1111/j.1398-9995.2006.01312.x-
dc.description.citedreferenceDunsky EH, 2006, ALLERGY, V61, P1235, DOI 10.1111/j.1398-9995.2006.01137.x-
dc.description.citedreferenceAntico A, 2006, ALLERGY, V61, P1236, DOI 10.1111/j.1398-9995.2006.01155.x-
dc.description.citedreferenceLue KH, 2006, PEDIATR ALLERGY IMMU, V17, P408, DOI 10.1111/j.1399-3038.2006.00443.x-
dc.description.citedreferencePassalacqua G, 2006, ALLERGY, V61, P849, DOI 10.1111/j.1395-9995.2006.01098.x-
dc.description.citedreferenceBahceciler NN, 2005, INT ARCH ALLERGY IMM, V136, P287, DOI 10.1159/000083956-
dc.description.citedreferenceSmith H, 2004, J ALLERGY CLIN IMMUN, V114, P831, DOI 10.1016/j.jaci.2004.06.058-
dc.description.citedreferenceTonnel AB, 2004, ALLERGY, V59, P491, DOI 10.1111/j.1398-9995.2004.00456.x-
dc.description.citedreferenceMarcucci F, 2001, ALLERGY, V56, P1091-
dc.description.citedreferenceGuez S, 2000, ALLERGY, V55, P369, DOI 10.1034/j.1398-9995.2000.00413.x-
dc.description.citedreferencePassalacqua G, 1998, LANCET, V351, P629-
dc.description.citedreferenceHirsch T, 1997, PEDIATR ALLERGY IMMU, V8, P21-
dc.description.citedreferenceREID MJ, 1993, J ALLERGY CLIN IMMUN, V92, P6-
dc.description.citedreferenceBOUSQUET J, 1992, IMMUNOTHERAPY RHINIT-
dc.description.citedreferenceVARNEY VA, 1991, BRIT MED J, V302, P265-
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