S-Space College of Medicine/School of Medicine (의과대학/대학원) Otorhinolaryngology (이비인후과학전공) Journal Papers (저널논문_이비인후과학전공)
Id2-, ROR gamma t-, and LT beta R-independent initiation of lymphoid organogenesis in ocular immunity
- Nagatake, Takahiro; Fukuyama, Satoshi; Kim, Dong-Young; Goda, Kaoru; Sato, Shintaro; Sagara, Hiroshi; Jetten, Anton M.; Akira, Shizuo; Sasakawa, Chihiro; Kiyono, Hiroshi; Kunisawa, Jun; Penninger, Josef M.; Inoue, Jun-ichiro; Akiyama, Taishin; Fujihashi, Kohtaro; Fukui, Yoshinori; Mimuro, Hitomi; Kaisho, Tsuneyasu; Yokota, Yoshifumi; Nochi, Tomonori; Igarashi, Osamu
- Issue Date
- ROCKEFELLER UNIV PRESS
- JOURNAL OF EXPERIMENTAL MEDICINE; Vol.206 11; 2351-2364
- The eye is protected by the ocular immunosurveillance system. We show that tear duct associated lymphoid tissue (TALT) is located in the mouse lacrimal sac and shares immunological characteristics with mucosa-associated lymphoid tissues (MALTs), including the presence of M cells and immunocompetent cells for antigen uptake and subsequent generation of mucosal immune responses against ocularly encountered antigens and bacteria such as Pseudomonas aeruginosa. Initiation of TALT genesis began postnatally; it occurred even in germ-free conditions and was independent of signaling through organogenesis regulators, including inhibitor of DNA binding/ differentiation 2, retinoic acid-related orphan receptor gamma t, lymphotoxin (LT) alpha 1 beta 2-LT beta R, and lymphoid chemokines (CCL19, CCL21, and CXCL13). Thus, TALT shares immunological features with MALT but has a distinct tissue genesis mechanism and plays a key role in ocular immunity.