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Absence of STAT1 disturbs the anticancer effect induced by STAT3 inhibition in head and neck carcinoma cell lines

Cited 14 time in Web of Science Cited 14 time in Scopus
Authors
Shim, Seon-Hui; Sung, Myung-Whun; Park, Seok-Woo; Heo, Dae Seog
Issue Date
2009-06
Publisher
SPANDIDOS PUBL LTD
Citation
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE; Vol.23 6; 805-810
Keywords
JAK inhibitionStat1head and neck squamous cell carcinomaStat3 inhibitionStat3
Abstract
The family of signal transducers and activators of transcription (STAT) are transcription factors. Among them, STAT I is associated with an apoptosis pathway, while STAT3 is associated with tumorigenicity in various cancer cells. In order to investigate the primary roles of STAT I and STAT3 in head and neck squamous cell carcinoma (HNSCC), we blocked STAT3 with two JAK inhibitors: AG490 (JAK2-STAT3 pathway inhibitor) and JAK total inhibitor. When we inhibited STAT3 with AG490, significant cell death was observed. However, in the case of JAK kinase total inhibitor, no cell growth retardation was observed. We focused on the role of STAT1 in this phenomenon. Suppression of STAT1 by si-RNA resulted in increased cell survival. Furthermore, the growth inhibitory effect of AG490 was reduced by treatment with si-RNA of STAT1. These results reveal that STAT1 is required to promote the tumor killing effect of STAT3 inhibition in HNSCC.
ISSN
1107-3756
Language
English
URI
https://hdl.handle.net/10371/78535
DOI
https://doi.org/10.3892/ijmm_00000196
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College of Medicine/School of Medicine (의과대학/대학원)Otorhinolaryngology (이비인후과학전공)Journal Papers (저널논문_이비인후과학전공)
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