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Effects of electroconvulsive shock on the phosphorylation of DARPP-32 in rat striatum

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dc.contributor.authorPark, Hye-Jean-
dc.contributor.authorCui, Feng Ji-
dc.contributor.authorRoh, Jae Woo-
dc.contributor.authorJung, Young Chul-
dc.contributor.authorKim, Yong Sik-
dc.contributor.authorKang, Ung Gu-
dc.contributor.authorKim, Se Hyun-
dc.date.accessioned2012-07-05T01:26:37Z-
dc.date.available2012-07-05T01:26:37Z-
dc.date.issued2009-11-30-
dc.identifier.citationPSYCHIATRY RESEARCH; Vol.170 1; 91-95ko_KR
dc.identifier.issn0165-1781-
dc.identifier.urihttps://hdl.handle.net/10371/78540-
dc.description.abstractDopamine- and cAMP-regulated phosphoprotein with molecular weight 32 kDa (DARPP-32) is a key integrative molecule in the dopaminergic and glutamatergic signaling pathways in the striatum. Electroconvulsive shock (ECS), which induces massive neuronal depolarization, can activate various signaling pathways. In this study we investigated whether ECS could affect the phosphorylation status of DARPP-32. Male Sprague-Dawley rats underwent ECS and were sacrificed by decapitation at 0, 2, 10, 60, and 180 min after treatment. The phosphorylations of Thr34 and Thr75 residues of DARPP-32 and Ser159 residue of cyclin-dependent kinase 5 (CDK5) were investigated in the striatum. The activity of protein phosphatase 1 (PP1) and the binding between DARPP-32 and PP1 were also analyzed. Thr34 phosphorylation of DARPP-32 increased immediately after ECS and this state was maintained for more than 60 min. The activity of PP1 decreased and the binding between PP1 and DARPP-32 increased in accordance with this phosphorylation pattern. However, the phosphorylation at Thr75 showed no significant change except for an initial transient decrease. The phosphorylation of CDK5, which is responsible for Thr75 phosphorylation of DARPP-32, did not exhibit significant fluctuations. Our findings indicate that ECS increases Thr34 phosphorylation of DARPP-32, and thus inhibits the activity of PP1. (c) 2008 Elsevier Ireland Ltd. All rights reserved.ko_KR
dc.description.sponsorshipThis studywas supported by a grant from the Korea Research Foundation (Grant No.
E00196), a Seoul National University Hospital Research Grant (05-2005-002-0), and a
grant from the Brain Research Center of the 21st Century Frontier Research Program
funded by the Ministry of Science and Technology (Grant No.M103KV010012-06K2201-
01210), Republic of Korea.
ko_KR
dc.language.isoenko_KR
dc.publisherELSEVIER IRELAND LTDko_KR
dc.subjectDARPP-32ko_KR
dc.subjectProtein kinase Ako_KR
dc.subjectProtein phosphatase 1ko_KR
dc.subjectStriatumko_KR
dc.subjectElectroconvulsive shockko_KR
dc.titleEffects of electroconvulsive shock on the phosphorylation of DARPP-32 in rat striatumko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor박혜진-
dc.contributor.AlternativeAuthor노재우-
dc.contributor.AlternativeAuthor정영철-
dc.contributor.AlternativeAuthor김세현-
dc.contributor.AlternativeAuthor김용식-
dc.contributor.AlternativeAuthor강웅구-
dc.identifier.doi10.1016/j.psychres.2008.07.002-
dc.citation.journaltitlePSYCHIATRY RESEARCH-
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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