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BOLD response during visual perception of biological motion in obsessive-compulsive disorder - An fMRI study using the dynamic point-light animation paradigm
DC Field | Value | Language |
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dc.contributor.author | Jung, Wi Hoon | - |
dc.contributor.author | Gu, Bon-Mi | - |
dc.contributor.author | Kang, Do-Hyung | - |
dc.contributor.author | Park, Ji-Young | - |
dc.contributor.author | Choi, Chi-Hoon | - |
dc.contributor.author | Kwon, Jun Soo | - |
dc.contributor.author | Lee, Jong-Min | - |
dc.contributor.author | Yoo, So Young | - |
dc.date.accessioned | 2012-07-05T01:29:57Z | - |
dc.date.available | 2012-07-05T01:29:57Z | - |
dc.date.issued | 2009-02 | - |
dc.identifier.citation | EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE; Vol.259, No.1; 46-54 | ko_KR |
dc.identifier.issn | 0940-1334 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78542 | - |
dc.description.abstract | Although research has shown that deficits in various cognitive functions may underlie obsessive-compulsive disorder (OCD), studies have not yet clarified the specificity and etiology of perception processing, particularly the perception of biological motion that is correlated with social cognition. We used functional magnetic resonance imaging (fMRI) to investigate neural activity associated with the perception of biological motion in OCD patients. The subjects were 15 patients with OCD and 15 age- and IQ-matched healthy volunteers. All subjects participated in a biological motion task in which they performed a one-back task signaling a repeated stimulus with a key press in each block condition to obligate attention to both types of stimuli. The biological motion versus scrambled motion contrast revealed that both OCD patients and healthy controls exhibited increased activation of the superior and middle temporal gyrus, the regions implicated in processing of biological motion, which is consistent with previous studies. However, direct comparison between OCD subjects and healthy controls indicated that patients with OCD exhibited increased activation in the right superior and middle temporal gyrus and the left inferior temporal and fusiform gyrus, and reduced activation in the right postcentral gyrus (BA 40) compared to healthy subjects. OCD patients exhibited increased activation in the ventral visual system, including the inferior temporal and fusiform gyrus. We observed a differential pattern of activity between OCD patients and healthy controls, indicating that OCD patients have functional differences related to the perception of biological motion. The differential activation between OCD patients and healthy subjects might contribute to the pathophysiological understanding of obsessive compulsive disorder. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | Springer Verlag | ko_KR |
dc.subject | biological motion | ko_KR |
dc.subject | OCD | ko_KR |
dc.subject | social functioning | ko_KR |
dc.subject | superior temporal gyrus | ko_KR |
dc.title | BOLD response during visual perception of biological motion in obsessive-compulsive disorder - An fMRI study using the dynamic point-light animation paradigm | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 정이훈 | - |
dc.contributor.AlternativeAuthor | 구본미 | - |
dc.contributor.AlternativeAuthor | 강도형 | - |
dc.contributor.AlternativeAuthor | 박지영 | - |
dc.contributor.AlternativeAuthor | 유소영 | - |
dc.contributor.AlternativeAuthor | 최치훈 | - |
dc.contributor.AlternativeAuthor | 이종민 | - |
dc.contributor.AlternativeAuthor | 권준수 | - |
dc.identifier.doi | 10.1007/s00406-008-0833-8 | - |
dc.citation.journaltitle | EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | - |
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dc.description.tc | 11 | - |
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