S-Space College of Medicine/School of Medicine (의과대학/대학원) Psychiatry (정신과학전공) Journal Papers (저널논문_정신과학전공)
알츠하이머병에 대한 비약물적 개입 : Nonpharmacological Interventions for Alzheimer`s Disease
Cited 1 time in Web of Science Cited 3 time in Scopus
- Issue Date
- KOREAN MEDICAL ASSOC
- JOURNAL OF THE KOREAN MEDICAL ASSOCIATION; Vol.52 11; 1069-1076
- Alzheimer`s disease ; Behavioral interventions ; Nonpharmacological intervention ; Cognitive intervention ; 알츠하이머병 ; 비약물적 개입 ; 인지적 개입 ; 행동적 개입
- Although acetylcholinesterase inhibitors (e.g., tacrine, donepezil, rivastigmine, and galantamine) and NMDA receptor antagonists (e.g., memantin) have demonstrated efficacy in the temporal symptomatic control of cognitive decline and daily function in Alzheimer`s disease (AD) patients, their effect is not good enough to restore premorbid function, nor is it maintained in the later stages. Therefore, nonpharmacological interventions are being increasingly advocated in order to optimize the cognition, affect and global functioning of AD patients. We reviewed the current nonpharmacological interventions for AD. Nonpharmacological interventions can be divided into two groups. One is cognitive interventions (e.g., Memory rehabilitations, Reality orientation, Reminiscence therapy and so on) and the other is behavioral interventions (e.g., unmet needs interventions, learning and behavioral interventions, environmental vulnerability and reduced stress-threshold interventions). Cognitive interventions are aimed to slow and compensate cognitive decline of AD patients. On the other hand, behavioral interventions are aimed to reduce neuropsychiatric symptoms (depression, anxiety, agitation, wandering, aggression and so on) of AD patients. Although many of the nonpharmacological interventions have proven beneficial for AD patients, their efficacy was still ambiguous. Randomized and controlled study with a larger sample size is needed to confirm efficacy of non pharmacological interventions.
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