S-Space College of Medicine/School of Medicine (의과대학/대학원) Psychiatry (정신과학전공) Journal Papers (저널논문_정신과학전공)
Neurocognitive effects of switching from methylphenidate-IR to OROS-methylphenidate in children with ADHD
- Kim, Yeni; Shin, Min-Sup; Kim, Jae-Won; Yoo, Hee-Jung; Kim, Boong-Nyun; Cho, Soo-Churl
- Issue Date
- JOHN WILEY & SONS LTD
- HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL; Vol.24(2); 95-102
- Objectives This study evaluated neurocognitive changes after switching from immediate release forms of methylphenidate (MPH-IR) to osmotic release oral system methylphenidate (OROS-MPH). Methods 102 children with attention-deficit/hyperactivity disorder (ADHD) participated in an open label, 28 day trial, performing neurocognitive test at baseline and at 28 days after the switch from MPH-IR to OROS-MPH. Results There were significant improvements in the commission error and the reaction time of both visual and auditory continuous performance tests (CPTs) at 28 days after switching from MPH-IR to OROS-MPH. A positive correlation was observed between the improvement in parent/caregiver-rated IOWA Conners total score (A IOWA) and the reduction in commission error (r= 0.3, p = 0.001) and reduction in reaction time variability (r= 0.3, p = 0.006) of visual CPT. In a linear regression model, the change in parent/caregiver-rated IOWA Conners scale total scores were significant predictors of change in commission error (beta = 0.3, p = 0.005, Cl = 0.4-2.3, adjusted R(2) = 0. 12) and RT variability (beta = 0.3, p = 0.004, Cl = 0.5-2.4, adjusted R(2) = 0.09) of visual CPT. Conclusions These data suggest that MPH-IR may be successfully switched to OROS-MPH treatment with associated improvements in neurocognitive performance. Large-scale controlled trials are needed to replicate these findings.
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