The Effect of Neontal MK-801 Treatment on ERK1/2-p70S6K-S6 Signal Pathway and Protein Synthesis Rate in the Frontal Cortex of Developing Rat Brain

Abstract

Background: Treatment of MK-801, a selective NMDA receptor antagonist, on neonatal rat induces long-term neurochemical and behavioral changes, which is suggested as the neurodevelopmental rat model of schizophrenia. Proper regulation of protein synthesis is required for neurodevelopment process.