S-Space College of Medicine/School of Medicine (의과대학/대학원) Psychiatry (정신과학전공) Journal Papers (저널논문_정신과학전공)
White matter alterations in male patients with obsessive-compulsive disorder
- Ha, Tae Hyon; Kang, Do-Hyung; Park, Jun Sung; Jang, Joon Hwan; Choi, Jung-Seok; Jung, Myung Hun; Lee, Jong-Min; Kwon, Jun Soo; Ha, Kyooseob; Choi, Chi-Hoon; Park, Ji-Young; Jung, W. Hoon
- Issue Date
- LIPPINCOTT WILLIAMS & WILKINS
- NEUROREPORT; Vol.20(7); 735-739
- anterior cingulate; fractional anisotropy; diffusion tensor imaging; obsessive-compulsive disorder; prefrontal white matter
- To investigate white matter abnormalities in patients with obsessive-compulsive disorder and to clarify the relationship between discrete white matter alterations and obsessive-compulsive symptom dimensions, the fractional anisotropy obtained from 25 male patients and 25 matched normal controls were analyzed. The patients had a significantly lower fractional anisotropy in the left anterior cingulate white matter than the controls. When stratified by clinical symptom dimensions, patients with a predominant aggressive/checking symptom dimension exhibited a significantly lower fractional anisotropy in the left anterior cingulate white matter, whereas patients with a predominant contamination/cleaning symptom dimension showed a significantly higher fractional anisotropy in the bilateral prefrontal white matter. Our findings provide evidence that obsessive-compulsive disorder may be a heterogeneous disease with distinct white matter changes.
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