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White matter alterations in male patients with obsessive-compulsive disorder
Cited 39 time in
Web of Science
Cited 42 time in Scopus
- Authors
- Issue Date
- 2009-05-06
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Citation
- NEUROREPORT; Vol.20(7); 735-739
- Keywords
- anterior cingulate ; fractional anisotropy ; diffusion tensor imaging ; obsessive-compulsive disorder ; prefrontal white matter
- Abstract
- To investigate white matter abnormalities in patients with obsessive-compulsive disorder and to clarify the relationship between discrete white matter alterations and obsessive-compulsive symptom dimensions, the fractional anisotropy obtained from 25 male patients and 25 matched normal controls were analyzed. The patients had a significantly lower fractional anisotropy in the left anterior cingulate white matter than the controls. When stratified by clinical symptom dimensions, patients with a predominant aggressive/checking symptom dimension exhibited a significantly lower fractional anisotropy in the left anterior cingulate white matter, whereas patients with a predominant contamination/cleaning symptom dimension showed a significantly higher fractional anisotropy in the bilateral prefrontal white matter. Our findings provide evidence that obsessive-compulsive disorder may be a heterogeneous disease with distinct white matter changes.
- ISSN
- 0959-4965
- Language
- English
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